世界中医药Issue(8)：1264-1269,6.DOI:10.3969/j.issn.1673-7202.2015.08.034
康艾注射液在肿瘤姑息治疗中的临床研究现状
Literature Review of Kang Ai Injection Applied in Palliative Treatment of Advanced Tumors
摘要
Abstract
Objective:To collect literature with Randomized Control Trials (RCTs)which were published before December 201 4, using system evaluation to assess the efficacy and safety of Kang Ai Injection in palliative treatment of advanced malignant tumors. Methods:Electronic database such as MEDLINE (Pubmed),Cochrane library,CBM,VIP,CNKI,Wanfang were searched through to collect appropriate studies about Kang Ai Injection combined with best supportive care (BSC)versus BSC alone in the palliative treatment of advanced tumors.All data were analyzed and processed by RevMan5.2 software provided by Cochrane.Re-sults:Eight RCTs,including 545 cases were involved into the study,but all of the studies were of low quality.The patients`im-provement of KPS was evaluated by meta-analysis.Heterogeneity text indicated data (χ2 =1 2.1 2,P =0.06,I2 =51 %).The re-sults with random effects model showed that Kang Ai Injection could improve KPS (RR =2.69,Z =4.54,P <0.00001 ,95%CI =[1 .75,4.1 2]).The improvement of the symptoms were analyzed by the method of descriptive statistics.All in all,three of four studies included indicated that Kang Ai Injection could improve the symptom of poor appetite in a larger deal.Four in six studies included showed that Kang Ai Injection could alleviate the pain in a larger amount.Meanwhile,all studies included indicated that Kang Ai Injection could better improve the symptoms of fatigue and insomnia compared with the control group.Conclusion:Adop-ting Kang Ai Injection in the palliative treatment of malignant tumors can improve the’symptoms of poor appetite,cancer pain,fa-tigue and insomnia as well as the quality of life.However,because of the low qualities of the studies,the results should be further proved by more normative RCTs.关键词
康艾注射液/随机对照/晚期肿瘤/姑息治疗Key words
Kang Ai injection/RCTs/Advanced tumor/Palliative treatment分类
医药卫生引用本文复制引用
王学谦,龚宏霞,林洪生,刘杰..康艾注射液在肿瘤姑息治疗中的临床研究现状[J].世界中医药,2015,(8):1264-1269,6.基金项目
中医药行业科研专项 （）
