世界中医药Issue(8)：1270-1275,6.DOI:10.3969/j.issn.1673-7202.2015.08.035
micro RNA在银屑病中医证候研究中的应用前景
The Prospect of Application of MicroRNA in Traditional Chinese Medicine Syndrome Research on Psoriasis Vulgaris
摘要
Abstract
MicroRNAisasmallnon-codingendogenousRNAmoleculewhichisconsistedofapproximately22nucleotides.Itde-generate target gene mRNA or suppress its protein translation through integration with the 3’UTR of the target gene.MicroRNA reg-ulates over 30%of protein coding genetic expression of the genome by cleavage and translation suppression.Keratinocyte cell pro-liferation and abnormal differentiation are the key characteristics of psoriasis,and these pathological changes are thought to origi-nate from cell immune system.T cell,dendritic cell and multiple immune-related cell factors were all involved.MicroRNA partici-pates in throughout the pathological process and plays an important role.MicroRNA expression specificity and sequence shows great similarity with the temporal-spatial characteristic of the syndrome.Introducing mircoRNA into psoriasis TCM syndrome re-search provides a new aspect to the topic through the interpretation of post-transcriptional level.关键词
microRNA/银屑病/证候Key words
MicroRNA/Psoriasisvulgaris/Syndrome分类
医药卫生引用本文复制引用
任磊,夏梦,潘厚儒,段行武..micro RNA在银屑病中医证候研究中的应用前景[J].世界中医药,2015,(8):1270-1275,6.基金项目
2013年国家自然科学基金项目“新型 T辅助细胞亚群 Th17、Th22及效应因子IL-22与银屑病辨证论治关系的研究” （）
