实用医学杂志2015，Vol.31Issue(14)：2252-2254,3.DOI:10.3969/j.issn.1006-5725.2015.14.004
肠系膜淋巴管结扎对重症急性胰腺炎大鼠肝损伤的影响
Effect of mesenteric lymphatic ligation on liver injury induced by severe acute pancreatitis in rats
摘要
Abstract
Objective To explore the effect of mesenteric lymphatic ligation on liver injury induced by severe acute pancreatitis. Methods 54 SD rats are randomly divided into sham-operation group (A), severe acute pancreatitis group (B) and severe acute pancreatitis and ligation group (C). Liver tissues were collected from each rat in 6, 12, and 24 h after ligation. Pathological changes in liver tissues were observed by haematoxylin and eosin staining. Levels of serum glutamic-pyruvic transaminase and glutamic oxalacetic transaminase were detected. Levels of TNF-α and IL-1 in liver homogenate were examined by enzyme linked immunosorbent assay. Results Under light microscopic examination, neutrophils and inflammatory exudate in hepatic lobule was increased as time prolonged in group B. Inflammation was reduced in group C as compared with group B.Levels of serum glutamic-pyruvic transaminase and glutamic oxalacetic transaminase were more significantly increased in groups B and C than in group A (P<0.05);while they were more significantly decreased in group C than in group B. Levels of TNF-αand IL-1 in liver homogenate were significantly increased in group B as compared with group A (P < 0.05); whereas they were more significantly decreased in group C than in group B at 24 h (P < 0.05). Conclusions Mesenteric lymphatic ligation can reduce liver injury in severe acute pancreatitis. Mesenteric lymphatic fluids may play an important role in severe acute pancreatitis.关键词
肠系膜淋巴管/结扎/重症急性胰腺炎/肝损伤Key words
Mesenteric lymph duct/Ligation/Severe acute pancreatitis/Liver injury引用本文复制引用
刘媛琪,王璐璐,陈立,谭晓勇,范玲,熊玉霞..肠系膜淋巴管结扎对重症急性胰腺炎大鼠肝损伤的影响[J].实用医学杂志,2015,31(14):2252-2254,3.基金项目
国家自然科学基金资助项目(编号:81102868) （编号:81102868）
