实用医学杂志2015，Vol.31Issue(14)：2351-2353,3.DOI:10.3969/j.issn.1006-5725.2015.14.035
叶酸受体α在子宫内膜癌患者血清中的表达及临床意义
Expression and significance of folate receptor alpha in serum of patients with endometrial carcinoma
摘要
Abstract
Objective To detect serum concentration of folate receptor alpha and to investigate its significance in the clinical application of patients with endometrial carcinoma. Methods Thirty-seven patients with endometrial carcinoma, 33 patients with endometrial hyperplasia and 10 healthy women were enrolled in this study. Sera were used to detect the the folate receptor alpha using an Enzyme-linked Immunosorbent Assay (ELISA) technique.The expression level of serum folate receptor alpha in different groups was analyzed. The correlation between the expression level of serum folate receptor alpha and age of patients, menopause, tumor morphology, myometrial invasion and clinical stage was was also analyzed in patients with endometrial carcinoma. Results Level of folate receptor alpha was successfully detected in serum of healthy women and patients with endometrial diseases. Level of folate receptor alpha in patients with endometrial carcinoma was much higher than that in patients with endometrial hyperplasia. Level of folate receptor alpha in patients with endometrial hyperplasia was also higher than that in the healthy controls, with significant difference (P < 0.05). In the endometrial carcinoma group,the levle of folate receptor alpha in serum was correlated with the clinical stage and myometrial invasion (P < 0.05), however, Level of folate receptor alpha was not correlated with the age of patients, menopause andtumor morphology(P > 0.05). Conclusion The Serum level of folate receptor alpha can be detected, and its expression will contribute to the diagnosis, treatment and predicting the prognosis of patients with endometrial carcinoma.关键词
子宫内膜癌/血清叶酸受体α/临床应用意义Key words
Endometrial carcinoma/Serum folate receptor alpha/The significance in the clinical application引用本文复制引用
何淑明,纪晓丹,李美灵..叶酸受体α在子宫内膜癌患者血清中的表达及临床意义[J].实用医学杂志,2015,31(14):2351-2353,3.基金项目
广东省科技计划项目(编号:2013B021800113) （编号:2013B021800113）
中山市科技计划项目(编号:2014A1FC020) （编号:2014A1FC020）
