实用医学杂志2015，Vol.31Issue(14)：2368-2371,4.DOI:10.3969/j.issn.1006-5725.2015.14.041
伏立康唑治疗恶性血液病并真菌感染临床应用Meta分析
Clinical application of Voriconazole treatment in invasive fungal infection for malignant hematology patients: a meta analysis
摘要
Abstract
Objective To estimate the efficacy and safety of Voriconazole as antifungal prophylaxis of invasive fungal infection ( IFI) for malignant hematology patients. Methods The randomized controlled trials of Voriconazole treatment in invasive fungal infection for malignant hematology patients (ended in September 2014) were searched from Cochrane library, Medline, Embase, Pubmed, CBM, CNKI, Blood database. The meta analysis were performed by RevMan5.0. Results Ten literatures reported in 1 773 cases, in which there was significantly difference in effective rate between Voriconazole and other antifungal agents such as Amphotericin-B, Itraconazole, Micafungin and Fluconazole(P < 0.000 01); Four literatures indicated that there was significantly difference in adverse event rate between Voriconazole and amphotericin-B (P < 0.00 001); no significantly difference in adverse event rate between Voriconazole and amphotericin-B(P = 0.57); no significantly difference in adverse event rate between Voriconazole and Micafungin (P = 0.69); no significantly difference in adverse event rate between Voriconazole and Fluconazole (P = 0.70); Subgroup analysis indicated that adverse event rate between Voriconazole and Itraconazole is P=0.001, P = 0.17 respectively. Conclusion Voriconazole showed relative high efficient and low toxicity characteristics in treatment of malignant hematology accompanied by invasive fungal infection. But with its widely clinical application, the clinical value of Voriconazole needs to be further tested.关键词
伏立康唑/恶性血液病/侵袭性真菌感染/Meta分析/系统评价Key words
Voriconazole/Malignant hematology patients/Invasive fungal infection/Meta analysis/Systemic evaluation引用本文复制引用
建磊磊,冀林华,李占全,崔森,苏娟,罗伟..伏立康唑治疗恶性血液病并真菌感染临床应用Meta分析[J].实用医学杂志,2015,31(14):2368-2371,4.基金项目
2013年度青海省人才"小高地"建设项目(编号:青人才字[2013]15号) （编号:青人才字[2013]15号）
青海大学综合实力提升工程——血液病学教学科研创新团队建设项目(编号:4056051001) （编号:4056051001）
