实用医学杂志2015，Vol.31Issue(15)：2440-2442,3.DOI:10.3969/j.issn.1006-5725.2015.15.009
舒芬太尼后处理对大鼠心肌缺血再灌注损伤的保护作用
The protective effect of sufentanil postconditioning on myocardial ischemia-reperfusion injury in rats
摘要
Abstract
Objective To evaluate the effect of sufentanil postconditioning on myocardial ischemia-reperfusion injury in rats, and to investigate the possible mechanism. Methods Thirty male Sprague-Dawley ratswere randomly divided into 5 groups (n = 6 each): sham group (group S), I/R group (group I/R), low dose of sufentanil postconditioning group (group SL), high dose of sufentanil postconditioning group (group SH) andsufentanil postconditioning plus wortmannin group (group WM). Different drugs were injected before reperfusion: normal saline (NS) and sufentanil 1 μg/kg in group SL, NS and sufentanil 3 μg /kg in group SH, wortmannin 15 μg/kg andsufentanil 1 μg/kgin group WM, and NS in group S and I/R. At the end of reperfusion, artery blood was collected for assessment of plasma cTnI concentration; And the heart was harvested for determination of infarct size (IS) and area at risk (AAR). Results Compared with group S, cTnI concentration was increasedin the rest groups (P< 0.01); Compared with group I/R, cTnI concentration was decreased in group SL, SH and WM, while IS/AAR reduced in group SL and SH (P < 0.01); Compared with group SL, cTnI concentration and IS/AAR were decreased in group SH while increased in group WM (P <0.01). Conclusion Sufentanil postconditioning could attenuate myocardial ischemia-reperfusion injury in rats, and the mechanism involved PI3K related pathway.关键词
舒芬太尼/药物后处理/心肌缺血再灌注损伤/PI3KKey words
Sufentanil/Pharmacological postconditioning/Myocardial ischemia reperfusion injury/PI3K引用本文复制引用
张燕,吴新海,黄飞,徐向辉,张晓晖..舒芬太尼后处理对大鼠心肌缺血再灌注损伤的保护作用[J].实用医学杂志,2015,31(15):2440-2442,3.基金项目
深圳市科创委基金资助( 编号:JCYJ20130402114317403) （ 编号:JCYJ20130402114317403）
