实用医学杂志2015，Vol.31Issue(15)：2463-2466,4.DOI:10.3969/j.issn.1006-5725.2015.15.017
体外γ-干扰素释放试验在儿童结核病密切接触者筛查结核病的作用
Role of IGRA in screening of tuberculosis for children with close TB contacts
摘要
Abstract
Objective To study the feasibility of in vitro release of γ-interferon tests (IGRA) in screening of tuberculosis for children with close TB contacts. Methods 185 children with close TB contacts were detected by IGRA at the pediatric clinic in our hospital. Results In IGRA-positive group, the rate of strong positive PPD (PDD≥15 mm) was 50.9%, which was higher than 9.1% in IGRA-negative group (X2 =37.263, P < 0.00). The morbidity rate for children with close TB contacts was 30.2% in IGRA-positive group, and it was significantly higher than 3.0% in IGRA-negative group (X2 = 28.928, P < 0.00). The sensitivity was 80% and the specificity was 77.6% for IGRA screening in children who had close contacts with TB patients. The sensitivity would be 95.0%, as the test was combined with PPD test. Conclusions IGRA screening in children with close TB contacts can increase the detection rate of tuberculosis and reduce imaging screening.关键词
结核病/γ-干扰素释放试验/密切接触者/儿童Key words
Close contact/IGRA/Tuberculosis/Children引用本文复制引用
黎燕琼,谭守勇,刘志辉,谭耀驹,黄艳君,孔少颜..体外γ-干扰素释放试验在儿童结核病密切接触者筛查结核病的作用[J].实用医学杂志,2015,31(15):2463-2466,4.基金项目
国家 "十二五" 重大科研项目 (编号:2012ZX100004903-001-002 ) （编号:2012ZX100004903-001-002 ）
广东省科技计划项目(编号:2012A030400002) （编号:2012A030400002）
