实用医学杂志2015，Vol.31Issue(15)：2486-2489,4.DOI:10.3969/j.issn.1006-5725.2015.15.024
不同剂量右美托咪定联合超低剂量纳洛酮对瑞芬太尼诱发的术后痛觉过敏的影响
Effect of combined use of different dose of exmedetomidine and ultra-low dose naloxoneon postoperative hyperalgesia induced by remifentanil
谭素云 1肖圣华 1王智钧 1韩全国 1刘永宏 1邱志建 1卢钊楷1
作者信息
- 1. 523945 广东医学院附属东莞市厚街医院麻醉科
- 折叠
摘要
Abstract
Obejective To explore the effect of combined use of dexmedetomidine and ultra-low dose naloxone on postoperative hyperalgesia induced by remifentanil. Method 80 ASA gradeⅠ-Ⅱ female patients who were scheduled to perform endoscopic sinus surgery (ESS) were randomly divided into four groups: purely remifentanil group (group R) and remifentanil plus different dosage dexmedetomidine and ultra-low dose naloxone group (group RDN1 ~ RDN3). Then the postoperative VAS on 30 min, 1 h, 2 h, 4 h, 8 h, 12 h and 24 h together with the firstpostoperative pain time , PCA press numbers , fentanyl usage and adverse reaction rate were recorded and evaluated. Results Average VAS of group R are higher than other groups in all 7 time points at the adjusted significant level of 0.0083, and group R > group RDN1 > group RDN2 > group RDN3, while differences between group RDN2 and RDN3 in all time points are not statistical significant.There is no difference between group RDN1 and group RDN2 inthe first postoperative pain time and the PCA press time at 1h after operation. Difference between group RDN2 and group RDN3 in the PCA press time at 24 h after operation was not significant, and the fentanyl usage of RDN groups are significantly less than group R. Conclusions Combined use of dexmedetomidine and ultra-low dose naloxone induced by remifentanil can improving patients′postoperative hyperalgesia , effect increase with the dose of dexmedetomidine increas , and the increasement is more sensitive in acute pain.关键词
右美托咪定/纳洛酮/瑞芬太尼/痛觉过敏Key words
Dexmedetomidine/Naloxone/Remifentanil/Hyperalgesia引用本文复制引用
谭素云,肖圣华,王智钧,韩全国,刘永宏,邱志建,卢钊楷..不同剂量右美托咪定联合超低剂量纳洛酮对瑞芬太尼诱发的术后痛觉过敏的影响[J].实用医学杂志,2015,31(15):2486-2489,4.
