中国组织工程研究Issue(33)：5338-5343,6.DOI:10.3969/j.issn.2095-4344.2015.33.018
巨噬细胞移动抑制因子在瘢痕疙瘩中的表达
Expression of macrophage migration inhibitory factor in keloid
李桂锋 1王春梅 2周显 3闫伦 2项晓飞 2徐伟 2杨思奋 2任家骠2
作者信息
- 1. 广州中医药大学第二临床医学院，广东省广州市 510502
- 2. 东莞康华医院烧伤整形科，广东省东莞市 523000
- 3. 东莞康华医院病理科，广东省东莞市 523000
- 折叠
摘要
Abstract
BACKGROUND:Macrophage migration inhibitory factor is involved in the process of a variety of diseases, and plays a very important role in the tumor, autoimmune diseases, inflammation, angiogenesis, fibrotic diseases and so on. These biological characteristics are similar to keloids. OBJECTIVE: To compare the distribution and number of macrophage migration inhibitory factor in normal skin, hypertrophic scar and keloid. METHODS: We colected 40 clinical pathological scar specimens after surgery, including 20 hypertrophic scars and 20 keloids. Another 10 samples of the normal skin were used as control group. Hematoxylin-eosin staining and immunohistochemistry staining were performed to test the expression of macrophage migration inhibitory factor in pathological scars and normal skin. RESULTS AND CONCLUSION:Macrophage migration inhibitory factor was positively expressed in the normal skin, hypertrophic scar and keloid, and the expression of macrophage migration inhibitory factor in keloid was significantly higher than that in hypertrophic scar and normal skin (P < 0.01). It means that the abnormal infiltration of macrophage migration inhibitory factor may be associated with the formation of keloid.关键词
组织构建/组织工程/巨噬细胞移动抑制因子/瘢痕疙瘩/增生性瘢痕/免疫组织化学Key words
Neoplasms/Immunity/Inflammation/Fibrosis分类
医药卫生引用本文复制引用
李桂锋,王春梅,周显,闫伦,项晓飞,徐伟,杨思奋,任家骠..巨噬细胞移动抑制因子在瘢痕疙瘩中的表达[J].中国组织工程研究,2015,(33):5338-5343,6.
