现代医药卫生Issue(17)：2583-2584,2587,3.DOI:10.3969/j.issn.1009-5519.2015.17.005
普伐他汀对动脉粥样硬化斑块稳定性和Lp-PLA2表达的影响
Influence of pravastatin on atherosclerotic plaque stability and Lp-PLA2 expression
摘要
Abstract
Objective To investigate the influence of pravastatin on the atherosclerotic plaque (AS) stability and serum Lp-PLA2 expression in rabbit. Methods 24 rabbits were randomly divided into the group A,B and C,8 cases in each group. The group A was non-model. The group B and C adopted the balloon pulling injury method for establishing the AS model. Then the pathological changes and serum Lp-PLA2 expression were observed. Results Compared with the group A,serum Lp-PLA2 levels at 5,10 weeks in the group B and C were increased significantly,the differences were statistically significant(P<0.05),moreover the increase of serum Lp-PLA2 level at 10 weeks in the group B was more obvious. Compared with the group B ,the serum Lp-PLA2 levels at 5,10 weeks in the group C was significantly decreased,the difference was statistically significant(P<0.05). The serum Lp-PLA2 levels at 5,10 weeks in the group B were significantly higher than those before experiment,the difference was sta-tistically significant(P<0.01). The serum Lp-PLA2 levels at 5,10 weeks in the group C were slightly higher than those before ex-periment. The pathological morphology and structure of AS plaque after pravastatin intervention were changed and the plaque structure trended to be more stable. Conclusion Pravastatin can reduce Lp-PLA2 level in the AS animal and promotes the AS plaque stability.关键词
普伐他丁/动脉粥样硬化/磷脂酶A2/脂蛋白类Key words
Pravastatin/Atherosclerosis/Phospholipases A2/Apolipoproteins引用本文复制引用
梁景岩,王英歌..普伐他汀对动脉粥样硬化斑块稳定性和Lp-PLA2表达的影响[J].现代医药卫生,2015,(17):2583-2584,2587,3.
