中国临床药理学杂志Issue(15)：1530-1532,3.DOI:10.13699/j.cnki.1001-6821.2015.15.019
姜黄素对糖尿病肾病大鼠的肾转化生长因子表达影响
Effect of the curcumin on diabetic nephropathy rats kidney transforming growth factor expression
摘要
Abstract
Objective To study effect of curcumin on expression of transforming growth factor in rats with diabetic kidney nephropathy.Methods The use of a single intraperitoneal injection of streptozotocin 58 mg · kg -1 to establish diabetic nephropathy in rats.Experimental group were given curcumin suspension 200 mg· kg-1 gavage, the normal group and model group were given equal 1%sodium carboxymethylcellu-lose volume.Observed by immunohistochemical staining of glomerular tubular regional expression of transforming growth factor.Results Com-pared with the model group, the rats of the experimental group 24 h urinary albumin, fasting blood glucose, serum transforming growth factor levels were significantly decreased (P<0.01).The glomerular, tubular region of transforming growth factor expression also decreased significantly ( P<0.01).Conclusion Curcumin can decrease the level of transfor-ming growth factor in serum and renal expression, and it has certain protective effect on diabetic nephropathy rats kidney.关键词
姜黄素/糖尿病肾病/转化生长因子Key words
curcumin/diabetic nephropathy/transforming growth factor-β1分类
医药卫生引用本文复制引用
尤丽菊,芦琨,田华..姜黄素对糖尿病肾病大鼠的肾转化生长因子表达影响[J].中国临床药理学杂志,2015,(15):1530-1532,3.基金项目
河南省商丘市2013年科技发展计划基金资助项目 （）
