中国临床药理学杂志Issue(16)：1645-1647,3.DOI:10.13699/j.cnki.1001-6821.2015.16.026
间充质干细胞的毒性作用研究
Study on the acute toxicity of different doses of mesenchymal stem cell in ICR mice
摘要
Abstract
Objective To observing the acute toxicity of mesenchymal stem cell ( MSC) in the ICR mice.Methods The ICR mice were divi-ded three groups based on the preliminary experiment , including high-dose of MSC group(2.0 ×108 cells・ kg-1 ), low-dose of MSC group(1.0 ×107 cells・ kg-1 ) and control group(normal saline), each group has 20 mice ( male and female, 1∶1).And then all the cells were tested respectively by the classic methods of acute toxicity in ICR mice. The reactions of mice to MSC was observed after single dosing of 20 mL・ kg-1 MSC through tail vein administration.Results There are no difference on the weight in three groups. But compared with the control group, the weight and weight index of the spleen and lung of the male mice in test-high and test-low dose group increased obviously. Besides, weight index of lung of the female mice in high -dose group increased evidently.Conclusion There are no obvious adverse drug reaction after administration MSC except that MSC has a stranded in some parts such as lung and spleen.关键词
间充质干细胞/表型鉴定/急性毒性/ICR小鼠/脏器系数Key words
mesenchymal stem cell/phenotypic identification/acute toxicity/ICR mice/organ coefficient分类
医药卫生引用本文复制引用
王冠华,荆宝琴,高畅,杨波,张云..间充质干细胞的毒性作用研究[J].中国临床药理学杂志,2015,(16):1645-1647,3.基金项目
国家重大新药创制专项基金资助项目 （）
