中国临床药理学杂志Issue(16)：1659-1661,1667,4.DOI:10.13699/j.cnki.1001-6821.2015.16.030
脂肪乳联合血液灌流透析对急性百草枯中毒犬肺损伤的疗效研究
Analysis of therapeutic effect of lipid emulsion combined with hemoperfusion and hemofiltration on acute paraquat poisoning and acute lung injury in dogs
摘要
Abstract
Objective To explore the therapeutic effect of lipid emul-sion combined with hemoperfusion and hemofiltration on acute paraquat poisoning and its consequence of acute lung injury.Methods A total of 24 dogs were randomly divided into A, B, C, D group.After paraquat ( PQ) 30 mg・ kg -1 was given by intramuscular injection, if there was no loss during the injection process, the model of poisoning was considered to be made successfully.Then the dog models in four groups were respec-tively treated with 4 mL・ kg -1 0.9%NaCl intravenous injection in group A, 4 mL・ kg -1 lipid emulsion intravenous injection in group B, 4 mL・ kg -1 0.9%NaCl intravenous injection combined with hemoperfu-sion and hemofiltration in group C, and 4 mL・ kg -1 lipid emulsion com-bined with hemoperfusion and hemofiltration in group D.The standards of tumor necrosis factor -α( TNF -α) , interleukin -1β( IL -1β) , IL-10 , human insulin like growth factor -1 ( IGF-1 ) , transforming growth factor-1 (TGF-β1) were determined at 0, 8, 12, 24, 36 and 48 h after starting the hemoperfusion and hemofiltration.Results Every index TNF-α, IL-1β, IL-10, IGF-1, TGF-β1 of the group A was significantly higher than that in the group B, C, D at the same section (P<0.05).IngroupB,thecytokinelevelsTNF-α,IL-1β,IL-10,IGF-1,TGF-β1weresignificantlyhigher compared with group D ( P<0.05).Conclusion Lipid emulsion combined with hemoperfusion and hemofiltration can be beneficial to relieve the lung injury induced by acute paraquat poisoning.关键词
脂肪乳/急性百草枯中毒/肺损伤/疗效Key words
lipid emulsion/acute paraquat poisoning/lung injury/therapeutic effect分类
医药卫生引用本文复制引用
王家泽,叶媛,王滨,孟新科..脂肪乳联合血液灌流透析对急性百草枯中毒犬肺损伤的疗效研究[J].中国临床药理学杂志,2015,(16):1659-1661,1667,4.基金项目
深圳市科技创新委员会2014年科技计划项目 （）
