中国全科医学Issue(26)：3181-3184,4.DOI:10.3969/j.issn.1007-9572.2015.26.014
青海地区子痫前期与可溶性人类白细胞相关抗原G和脐动脉血流动力学相关性研究
Correlation Between Serum Level of sHLA-G,Hemodynamic Change of Umbilical Artery and Preeclampsia in Qinghai Province
摘要
Abstract
Objective To investigate the correlation between umbilical artery blood flow changes and serum level of sHLA-G in patients with preeclampsia in Qinghai Province. Methods We enrolled 90 pregnant women who underwent childbirth in the Affiliated Hospital of Qinghai University from September to December 2014. Among them,30 subjects were normal in childbirth,26 subjects were with mild preeclampsia and 34 were with severe preeclampsia. Before delivery,venous blood was sampled from the three groups of subjects. Then ELISA method was employed to test serum level of sHLA-G,and doppler ultrasonography was used to detect PI,RI and S/D. Results The three groups were significantly different(P<0. 001) in serum level of sHLA-G,PI,RI and S/D;the mild preeclampsia group and the severe preeclampsia group were lower( P<0. 05)in serum level of sHLA - G and higher(P <0. 05)in PI,RI and S/D than normal childbirth group;the severe preeclampsia group was lower(P<0. 05)in serum level of sHLA-G and higher(P<0. 05)in PI,RI and S/D than the mild preeclampsia. The three groups were significantly different in the distribution of urine protein(U=80. 416,P<0. 05). The correlation analysis showed that,among the patients with preeclampsia,the urine protein was negatively correlated with serum level of sHLA-G(r= -0. 873,P<0. 05),serum level of sHLA-G was negatively correlated with S/D(r= -0. 784,P<0. 05),serum level of sHLA-G was negatively correlated with RI(r= -0. 522,P<0. 05),and serum level of sHLA-G was negatively correlated with PI(r= -0. 638,P<0. 05). Conclusion The serum level of sHLA-G and the hemodynamic change of umbilical artery is correlated with severity degree of preeclampsia,and serum level of sHLA-G is correlated with the hemodynamic change of umbilical artery,which helps to predict the intrauterine environment for fetus and childbirth outcome.关键词
先兆子痫/HLA抗原/脐动脉/青海Key words
Pre-eclampsia/HLA antigens/Umbilical arteries/Qinghai分类
医药卫生引用本文复制引用
谢莹莺,赵海宁,杨娟,李凤莲,杨卓加,祁春琳..青海地区子痫前期与可溶性人类白细胞相关抗原G和脐动脉血流动力学相关性研究[J].中国全科医学,2015,(26):3181-3184,4.基金项目
青海省（应用）基础研究计划项目 （）
