中国全科医学Issue(27)：3290-3293,3299,5.DOI:10.3969/j.issn.1007-9572.2015.27.007
隐源性肝硬化患者发生肝细胞肝癌的危险因素探讨
Risk Factors for the Occurrence of Hepatocellular Carcinoma in patients With Cryptogenic Cirrhosis
摘要
Abstract
Objective To investigate the risk factors for the occurrence of hepatocellular carcinoma( HCC)in patients with cryptogenic cirrhosis( CC) . Methods 241 CC patients who accorded with the inclusion and exclusion criteria from the First Teaching Hospital of Xinjiang Medical University between July 2009 and July 2014 were enrolled in the study. According to the results of diagnoses,the subjects were divided into two groups:CC group(n =222)and CC +HCC group(n =19). Comparison was made between the two groups in gender, age, ethnic group, body mass, whether complicated with hypertension,whether complicated with diabetes mellitus,family history of malignant tumor,drug allergy history,Child-Pugh score, hemoglobin, mean corpuscular volume, globulin, triacylglycerol, total cholesterol, uric acid, creatinine and urine protein. Results Univariate conditional Logistic regression analysis showed that age,urine protein and whether complicated with hypertension were influencing factors for HCC in CC patients( P <0. 05 ) . Multivariate non - conditional Logistic stepwise regression analysis showed that,with α=0. 05 as the outstanding standard,the variables that entered regression model included age and being complicated with hypertension(P<0. 05). Conclusion Age and hypertention are risk factors for HCC in patients with CC. The elevation of blood pressure and age should be paid special attention and evaluated correctly,in order to reduce the risk of HCC in CC patients.关键词
肝硬化/高血压/癌,肝细胞/危险因素Key words
Liver cirrhosis/Hypertension/Carcinoma,hepatocellular/Risk factors分类
医药卫生引用本文复制引用
范晓棠,张建庆,王月,祝君文,希尔娜依·阿不都黑力力,冯娟,陈兰,何方平..隐源性肝硬化患者发生肝细胞肝癌的危险因素探讨[J].中国全科医学,2015,(27):3290-3293,3299,5.基金项目
新疆维吾尔自治区自然科学基金资助项目 （）
