摘要
Abstract
Objective To investigate the effect of sulodexide on serum and urine MCP-1 in patients with type 2 diabetic nephropathy. Methods Enrolled 84 patients with type 2 diabetic nephropathy who received hospitalized treatment in the Department of Nephrology Jingzhou First People's Hospital from January 2012 to December 2013. The patients were divided into control group and observation group using random number table method, with each group 42 patients. Both groups were administrated with conventional subcutaneous infection of insulin to control blood glucose;the observation group was also administrated with the injection of 600 LSU sulodexide once per day for two weeks by the means of intravenous drip,and then the group was orally administrated with 250 LSU sulodexide soft capsule twice per day for ten weeks;the observation lasted for all together 12 weeks. The serum creatinine( Scr),urea nitrogen( BUN),fasting blood sugar( FBS),24 h urinary protein, coagulation function,serum and urine MCP-1 level were measured before and after treatment. Results Before treatment,the two groups were not significantly different(P>0. 05)in Scr,BUN,FBS,24 h urinary protein quantitation,PT,APTT,TT, FIB and serum and urine MCP-1 level. After treatment,the two groups were not significantly different(P >0. 05)in Scr, BUN,FBS,PT,APTT,TT and FIB;after treatment,the observation group was lower(P<0. 05)than the control group in 24 h urinary protein quantitation and serum and urine MCP-1 level. Conclusion Sulodexide can reduce urine protein excretion in patients with diabetic nephropathy,the mechanism of which may be related to the reduction of serum and urine MCP-1 secretion.关键词
糖尿病肾病/蛋白尿/舒洛地特/单核细胞趋化蛋白1Key words
Diabetic nephropathies/Proteinuria/Sulodexide/Monocyte chemotactic protein-1分类
医药卫生
