中国药房Issue(26)：3649-3651,3.DOI:10.6039/j.issn.1001-0408.2015.26.14
他克莫司血药浓度监测在膜性肾病治疗中的意义
Significance of Tacrolimus Blood Concentration Monitoring to the Therapy of Membranous Nephropathy
摘要
Abstract
OBJECTIVE:To investigate the significance of tacrolimus blood concentration monitoring to the therapy of mem-branous nephropathy. METHODS:41 patients with membranous nephropathy received tacrolimus,and the blood concentration of ta-crolimus reached to steady state. The trough concentration of tacrolimus was determined by EMIT. The patients were followed up, and clinical therapeutic efficacies were recorded. The relationship of blood concentration of tacrolimus with clinical efficacy was evaluated by SPSS 16.0 software. RESULTS:The blood concentration of tacrolimus was(7.47±2.74)ng/ml in complete remission (CR)group,(5.72±1.19)ng/ml in partial response(PR)group,and(3.30±1.08)ng/ml in no response(NR)group,with total remission rate of 75.61%. The blood concentration of CR group was the highest,followed by PR group and NR group,there was statistical significance among 3 groups(P<0.05). CONCLUSIONS:The clinical efficacy of tacrolimus in the treatment of nephrot-ic syndrome is correlate to the blood concentration intimately. Trough concentration monitoring of tacrolimus has important signifi-cance to the treatment of membranous nephropathy.关键词
他克莫司/膜性肾病/血药浓度/临床疗效Key words
Tacrolimus/Membranous nephropathy/Blood concentrations/Clinical efficacy分类
医药卫生引用本文复制引用
叶冬梅,吴潮清,申庆荣,金雪峰..他克莫司血药浓度监测在膜性肾病治疗中的意义[J].中国药房,2015,(26):3649-3651,3.基金项目
广西医疗卫生重点科研课题（No.桂卫重2012105）；广西壮族自治区卫生厅自筹经费科研课题 （）
