摘要
Abstract
OBJECTIVE:To investigate the effect of intravitreal injection of ranibizumab on visual acuity and GAS6,SDF-1 and VEGF levels in serum of patients with proliferative diabetic retinopathy lesions. METHODS:56 patients diagnosed as prolifera-tive diabetic retinopathy in our hospital during Mar. 2012 to Mar. 2014 were analyzed retrospectively and divided into simple lateral eyes group(29 cases)and bilateral eyes group(27 cases). All patients received single intravitreal injection of ranibizumab. The se-rum levels of GAS6,SDF-1 and VEGF were detected before treatment and 1,4 and 8 weeks after treatment. The visual acuity of patients were detected before treatment and 1 week after treatment. RESULTS:1,4 and 8 weeks after treatment,the serum levels of GAS6,SDF-1 and VEGF in 2 groups were decreased significantly,with statistical significance(P<0.05);but there was no sta-tistical significance between 2 groups(P>0.05). 1 week after treatment,the number of letter which had been seen by patient’s BC-VA were increased,compared to before treatment,with statistical significance(P<0.05);but there was no statistical significance between 2 groups(P>0.05). CONCLUSIONS:Intravitreal injection of ranibizumab can improve visual acuity of patients with pro-liferative diabetic retinopathy.关键词
糖尿病性视网膜病变/雷珠单抗/玻璃体腔/人生长停滞特异性蛋白6/人基质细胞衍生因子1/血管内皮细胞生长因子/视力Key words
Diabetic retinopathy/Ranibizumab/Vitreous cavity/GAS6/SDF-1/VEGF/Visual acuity分类
医药卫生
