中国医科大学学报2015，Vol.44Issue(8)：738-741,757,5.
Fascin在乳腺癌中的表达与临床特征及预后的相关性研究
Correlation Study of the Fascin Expression and Prognosis in Breast Cancer
王鑫 1徐岩 1谭继超 1孙丁 1徐惠绵1
作者信息
- 1. 中国医科大学附属第一医院胃肠肿瘤外科,沈阳 110001
- 折叠
摘要
Abstract
Objective To investigate the relationship between the expression of Fascin and breast cancer prognosis. Methods Paraffin sections of breast cancer from 110 patients were investigated by immunohostochemistry with monoclonal anti-fascin antibody. Data of the Fascin expression and clinicopathological variables were analyzed for disease-free survival(DFS)and overall survival(OS)by Kaplan-miere and cox model. Results The expression of Fascin was significantly associated with ER negative,PR negative and lymph node metastasis,but not with age,HER2 status and tumor size. The patients with positive expression of Fascin had shorter disease free survival time than those without Fascin expression. Conclusion High expression of Fascin is associated with poor prognosis in breast cancer. Fascin is an independent prognostic indicator of disease-free survival time.关键词
Fascin/乳腺癌/预后Key words
Fascin/breast cancer/prognosis分类
医药卫生引用本文复制引用
王鑫,徐岩,谭继超,孙丁,徐惠绵..Fascin在乳腺癌中的表达与临床特征及预后的相关性研究[J].中国医科大学学报,2015,44(8):738-741,757,5.
