中国医学创新Issue(26)：32-35,4.DOI:10.3969/j.issn.1674-4985.2015.26.010
乳腺浸润性导管癌超声特征与分子生物学表达的相关性研究
Correlations of Ultrasonographic Features and Molecular Biology Expressions in Invasive Duct Carcinoma of Breast
摘要
Abstract
Objective:To investigate the correlations between ultrasonographic features and molecular biological indexes such as ER(estrogen receptor),PR(progesterone receptor),C-erbB-2 (human epidermal growth factor receptor 2)and Ki-67 in invasive duct carcinoma of breast(IDC).Method:The data of 107 IDC patients who were in our hospital from January 2012 to June 2014 were collected.Their ultrasonographic data and immunohistochemical pathologic results were analyzed.Result:The positive expression rates of ER,PR in patients with spiculation were higher than those in patients without spiculation,the positive expression rates of ER,C-erbB-2 and Ki-67 in patients with microcalcification were higher than those in patients without microcalcification,the positive expression rate of C-erbB-2 in patients with suspicious lymph node was higher than that in patients without suspicious lymph node,the positive expression rate of C-erbB-2 in patients with rich blood flow signals was higher than that in patients with poor blood flow signals,the differences above were all statistically significant(P<0.05).Conclusion:There is a certain correlation between ultrasonographic features and molecular biology markers in invasive duct carcinoma of breast. The expression results of ER,PR,C-erbB-2 and Ki-67 of IDC can be predicted according to the ultrasonographic features,which can provide a basis for the biologic behavior assessment,prognosis and clinical treatment.关键词
乳腺肿瘤/超声/分子生物学Key words
Breast neoplasms/Ultrasonography/Molecular biology引用本文复制引用
郭冀鲁,李远,牛俊波,陈伟娟,贾守艇,刘学智,冯勇,张秀江,李建国..乳腺浸润性导管癌超声特征与分子生物学表达的相关性研究[J].中国医学创新,2015,(26):32-35,4.基金项目
山东省潍坊市卫生局科研课题 （）
