中国医院用药评价与分析2015，Vol.15Issue(8)：1037-1040,4.DOI:10.14009/j.issn.1672-2124.2015.08.018
长春西汀注射液与临床常用输液配伍的稳定性考察
Observation of Compatible Stability of Vinpocetine Injection and the Commonly Used Clinic Infusions
邓丽 1汪秋兰 1王世民 2施春阳 1方建国 1王文清1
作者信息
- 1. 华中科技大学同济医学院附属同济医院药学部,湖北武汉 430030
- 2. 武汉华龙生物制药有限公司新药研发部,湖北武汉 430030
- 折叠
摘要
Abstract
OBJECTIVE:To investigate the compatible stability of vinpocetine injection respectively mixed with 5%glucose injection and 0. 9% sodium chloride. METHODS: After respectively mixed vinpocetine injection with two kinds of commonly used infusions ( 5% glucose injection and 0. 9% sodium chloride ) , the infusion solutions were stored at room temperature ( 20-25 ℃) , the changes of appearance, pH value and particulate matter of infusion solutions were investigated within 8h. The content of vinpocetine in infusion solution was determined by High Performance Liquid Chromatography( HPLC) . RESULTS: After mixed with 5% glucose injection and 0. 9% sodium chloride, the infusion solutions were stored at room temperature(20-25 ℃) for 8 h, there were no obvious change in the appearance and pH value, particulate matter and the content of vinpocetine in infusion solution. CONCLUSIONS:At room temperature ( 20-25 ℃) , vinpocetine injection respectively mixed with 5% glucose injection and 0. 9%sodium chloride for 8h can remain keep stable.关键词
长春西汀/输液/配伍稳定性/不溶性微粒Key words
Vinpocetine/Infusion/Compatible stability/Particulate matter分类
医药卫生引用本文复制引用
邓丽,汪秋兰,王世民,施春阳,方建国,王文清..长春西汀注射液与临床常用输液配伍的稳定性考察[J].中国医院用药评价与分析,2015,15(8):1037-1040,4.
