中国医院用药评价与分析Issue(9)：1147-1149,3.DOI:10.14009/j.issn.1672-2124.2015.09.005
低剂量罗红霉素联合鼻腔冲洗预防鼻咽癌放疗术后鼻窦炎的疗效观察
Observation of Efficacy of Low Dose Roxithromycin Combined with Nasal Douche in Prevention of Nasosinusitis after Nasopharyngeal Carcinoma Radiotherapy
摘要
Abstract
OBJECTIVE:To investigate the clinic efficacy of low dose roxithromycin combined with nasal douche in prevention of nasosinusitis after nasopharyngeal carcinoma ( NPC) radiotherapy .METHODS:128 cases with NPC that confirmed by pathological diagnosis from Jan .2011 to Mar.2014 in three hospitals were divided into observation group with 62 cases and control group with 66 cases via the random number table .The control group received conventional radiotherapy;based on the control group , the treatment group was additionally given low dose roxithromycin orally combined with nasal douche of 0.9% sodium chloride injection .The incidence of nasosinusitis , headache , runny nose , rhinobyon and hyposmia scores before and after treatment were compared between two groups .RESULTS: The incidence of nasosinusitis in observation group was 9.68%( 6/62 ) , which was significantly lower than that in control group [22.73%(15/66)], with statistically significant difference (P <0.05).Before treatment, there were no statistically significant difference between two groups in headache , rhinobyon , hyposmia and runny nose scores ( P>0.05 ) .After treatment , headache , rhinobyon , hyposmia and runny nose scores in observation group were significant higher than that in control group , with statistically significant difference ( P <0.05 ) .CONCLUSIONS: To treat the patients with NPC with radiotherapy , oral roxithromycin and nasal douche of 0.9% sodium chloride injection , can effectively reduce the incidence of nasosinusitis after radiotherapy , create better life conditions and improve the quality of life for the patients after radiotherapy .关键词
鼻咽癌/罗红霉素/鼻腔冲洗/鼻窦炎Key words
Nasopharyngeal carcinoma/Roxithromycin/Nasal douche/Nasosinusitis分类
医药卫生引用本文复制引用
王跃武,黎刚,王敏,张群贵,丁勇..低剂量罗红霉素联合鼻腔冲洗预防鼻咽癌放疗术后鼻窦炎的疗效观察[J].中国医院用药评价与分析,2015,(9):1147-1149,3.基金项目
2014年江西省赣州市科技计划项目 （）
