中华骨质疏松和骨矿盐疾病杂志Issue(3)：219-222,223,5.DOI:10.3969/j.issn.1674-2591.2015.03.006
尿钙／肌酐比值不能替代24小时尿钙检测诊断高尿钙
Spot urine calcium-to-creatinine ratios be not used to diagnose hypercalciuria replacing 24 hours urinary calcium
刘峥 1张鹏睿 1潘永华 1王广 1宁志伟1
作者信息
- 1. 100020 北京，首都医科大学附属北京朝阳医院内分泌科
- 折叠
摘要
Abstract
Objective To determine extent of correlation of spot ratio of urine calcium to reatinine ( UCa/Cr) with 24 hours urine calcium (24 hUC) and to find the cut point of UCa/Cr for diagnosis.We also evaluated the accordance of UCa/Cr and 24 hUC measurements.Methods We collected the 24-hour urine samples and the spot urine samples, detected 24 hUC, urinary calcium and creatinine, then calculated UCa/Cr.The receiver operating characteristic (ROC) curve was drawn to find the cut point of UCa/Cr for diagnosis of hypercalciuria.We evaluated the sensitivity, specificity and the misdiagnosis rate and consistency of UCa/Cr with the 24 hUC with Bland-Altman analysis.Results UCa/Cr were positively correlated with 24 hUC significantly ( r=0.510 , 95%confidence interval:0.38-0.62 , P=0.000).When we made the 24 hUC the golden standard, the cut point of UCa/Cr was 0.162, with the sensitivity and specificity of 61.5% -72.7% and 67.8% -75.5%, respectively.The misdiagnosis rate were as high as from 54.7% to 73.1%.UCa/Cr was average 66.2 mg lower than 24 hUC with 95%confidence interval of -324.5 to 192. Conclusion UCa/Cr measurements, although has a reasonable correlation, but poor consistency with the 24 hUC measurements.Clinicians should still use the 24 hUC to diagnose hypercalciuria compared to spot UCa/Cr ratio.关键词
尿钙与尿肌酐比值/高尿钙/骨质疏松/肾结石Key words
urine calcium-to-creatinine ration/hypercalciuria/osteoporosis/nephrolithiasis分类
医药卫生引用本文复制引用
刘峥,张鹏睿,潘永华,王广,宁志伟..尿钙／肌酐比值不能替代24小时尿钙检测诊断高尿钙[J].中华骨质疏松和骨矿盐疾病杂志,2015,(3):219-222,223,5.
