安徽医科大学学报2015，Vol.50Issue(9)：1267-1270,4.
EB病毒miR-BART4*和miR-BART18-3p在鼻咽癌中的表达及意义
Expression of EB virus miR-BART4* and miR-BART18-3 p in nasopharyngeal carcinoma and its significance
摘要
Abstract
Objective To analyze expression of EB virus ( EBV) miRNAs in nasopharyngeal carcinoma( NPC) tis-sue, explore molecular mechanism of EBV induced NPC and biomarker for prevention and diagnosis of NPC. Meth-ods 36 cases of nasopharyngeal poorly differentiated squamous cell carcinoma tissues and 32 cases of chronic na-sopharyngeal mucositis tissues were collected. Expressions of EBV miRNAs ebv-miR-BART4? and ebv-miR-BART18-3 p were tested in these tissues by quantitative real-time PCR; the expression level of EBV miRNAs was analyzed in both tissue groups. Results The expressions( Ct) of ebv-miR-BART4? and ebv-miR-BART18-3p were (26. 97 ± 2. 67) and (27. 02 ± 2. 32) in NPC tissue, (38. 49 ± 3. 05) and (39. 39 ± 2. 16)in nasopharyngeal mu-cosa inflammation tissue, the expressions of two ebv-miRNAs were significantly higher in NPC tissue than that in nasopharyngeal mucosa inflammation tissue ( P <0. 01 ) . Conclusion NPC may be induced by EBV through the high expression of ebv-miR-BART4?and ebv-miR-BART18-3p. They are potential biological molecular markers for the diagnosis and treatment of NPC.关键词
鼻咽癌/生物分子标志物/EB病毒微小RNAKey words
nasopharyngeal carcinoma/biological marker/ebv-miRNAs分类
医药卫生引用本文复制引用
李璐,王建红,黄辉,范才文,肖胜军,熊伟明,雷迅..EB病毒miR-BART4*和miR-BART18-3p在鼻咽癌中的表达及意义[J].安徽医科大学学报,2015,50(9):1267-1270,4.基金项目
广西自然科学基金项目(编号:2011GXNSFD018034) （编号:2011GXNSFD018034）
广西教育厅科研项目(编号:2013YB168) （编号:2013YB168）
广西医学科学实验中心开放基金专项项目(编号:KFJJ2010-51) （编号:KFJJ2010-51）
广西科学研究与技术开发计划项目(编号:桂科攻0592007-1J) （编号:桂科攻0592007-1J）
