安徽医科大学学报2015，Vol.50Issue(9)：1293-1296,4.
人参皂苷Rg3对鼻咽癌放疗患者细胞免疫功能的影响
The effect of Rg3 ginsenosides on cellular immune function of nasopharyngeal carcinoma patients with radiotherapy
摘要
Abstract
Objective To evaluate the effect of ginsenoside-Rg3 on cellular immune function of nasopharyngeal carcinoma patients with radiotherapy. Methods 50 nasopharyngeal carcinoma patients with radiotherapy were ran-domly divided into Rg3 group ( n=25 ) and control group ( n=25 ) . After the radiotherapy, the peripheral blood lymphocy of each group were collected. MTT method was used to detect lymphocyte proliferation. Lymphocyte sub-group was detected by Flow Cytometry/financal capacity model. IgG,IgM and Th1/Th2 cytokines was detected by ELISA. Results Ginsenoside Rg3 could promote the proliferation of lymphocytes in patients with nasopharyngeal carcinoma radiotherapy,upregulation of CD4 +,CD4 +/CD8 +,IgG,IgM,IL-2,downregulation of CD8 +,IL-6,and showed dose dependent. Conclusion Rg3 ginsenosides can significantly enhance the peripheral blood lymphocyte immune function of nasopharyngeal carcinoma patients with radiotherapy. Rg3 ginsenosides may be a potential im-mune immunosuppression caused by nasopharyngeal carcinoma radiotherapy enhancer antagonism.关键词
人参皂苷Rg3/鼻咽癌/放疗/淋巴细胞Key words
Rg3 ginsenosides/nasopharyngeal carcinoma/radiotherapy/lymphocyte分类
医药卫生引用本文复制引用
何斌,钱立庭,江浩..人参皂苷Rg3对鼻咽癌放疗患者细胞免疫功能的影响[J].安徽医科大学学报,2015,50(9):1293-1296,4.基金项目
安徽省自然科学基金(编号:1408085MH190) （编号:1408085MH190）
