安徽医科大学学报Issue(11)：1574-1578,5.
1，25-二羟维生素 D3对免疫性血小板减少症模型小鼠的治疗作用
The therapeutic effect of 1,25-dihydroxyvitamin D3 on ITP mice model
摘要
Abstract
Objective To observe and analyze the therapeutic effect of 1,25-dihydroxyvitamin D3 on the immune thrombocytopenia(ITP)model in mice.Methods 44 BALB /c mice were divided into three groups:normal control group,model group and 1,25-dihydroxyvitamin D3 treatment group.The model group was given the GP-APS intra-peritoneally,while the treatment group,on the basis of the model group,was administered 100 ng/d of 1,25-di-hydroxyvitamin D3 by intravenous injection,and the normal control group was given the same volume of saline through both intraperitoneal and intravenous injection.The mice were taken blood samples after 24 hours of each administration,recorded their weights and measured platelet accounts and bleeding tendencies.After two weeks of injection,the mice were sacrificed and dissected,smeared with the bone marrow that had been taken out,counted the number of megakaryocyte under the microscope.Assessed the therapeutic effect of 1,25-dihydroxyvitamin D3 on the model mice in several aspects.Results From the 10th day of the injection,the food-intake of the treatment group was markedly increased,the spirit status and reaction was gradually recovered;the body weight and platelet account,compared with the model group,were both significantly increased (P <0.05);bleeding tendency evident was markedly decreased (P <0.05);the number of the platelet-forming megakaryocyte was higher than the model group and lower than the normal control group,while the number of the megakaryocyte was lower than the model group and higher than the normal control group,the difference was statistically significant.Conclusion 1,25-di-hydroxyvitamin D3 shows some influence on the improvement of general status,the rise of body weight and platelet account,the reduction of bleeding tendency and the promotion of platelet's production of the model mice.关键词
免疫性血小板减少症/动物模型/1,25-二羟维生素D3Key words
immune thrombocytopenia/animal model/1,25-dihydroxyvitamin D3分类
医药卫生引用本文复制引用
顾悦,刘莉侠,杨明珍,曾庆曙,黄震琪,吴炜,安福润..1，25-二羟维生素 D3对免疫性血小板减少症模型小鼠的治疗作用[J].安徽医科大学学报,2015,(11):1574-1578,5.基金项目
安徽省自然科学基金 （）
