安徽医科大学学报Issue(11)：1665-1668,1669,5.
急性心梗患者介入前后血清炎性细胞因子水平变化与早期预后关系
Correlation between peri-procedural changes of serum inflammatory cytokines and early prognosis in patients with acute myocardial infarction undergoing percutaneous coronary intervention
摘要
Abstract
Objective To investigate the variation and clinical significance of serum levels of inflammatory cyto-kines after percutaneous coronary intervention (PCI)treatment in acute myocardial infarction (AMI)patients. Methods 118 incipient AMI patients with successful underwent PCI (Defined as treatment group,blood samples were collected from pre-operation,12 h after operation,24 h after operation,48 h after operation and 90 d postop-erative follow-up period)and 52 AMI patients with diagnostic coronary angiography (CAG)(Defined as control group,blood samples were collected prior to CAG,12 h after CAG,24 h after CAG,48 h after CAG and 90 d fol-low-up period)were enrolled in this study.Serum levels of IL-6,IL-18,hs-CRP,TNF-αand MMP-9 were detec-ted in all the subjects by enzyme-linked immune sorbent assay(ELISA)and major adverse cardiac events(MACE) occurrence rate was analyzed in 90 days followed-up cases.Results No significant differences in baseline levels of IL-6,IL-18,hs-CRP,TNF-αand MMP-9 were found in the two study groups(P >0.05).No significant differences of levels of IL-6,IL-18,hs-CRP,TNF-αand MMP-9 were found after CAG in control group (P >0.05).The serum levels of IL-6,IL-18,hs-CRP and TNF-αafter PCI were significantly increased (P <0.01 )while no significant differences were found in level of MMP-9 (P >0.05)in PCI group.There were significant differences of levels of IL-6,IL-18,hs-CRP and TNF-αbetween MACE group and without MACE group after PCI.The multivariable lo-gistic analysis showed that IL-6,IL-18,hs-CRP and TNF-αwere risk factors of MACE after 90 days follow-up. Conclusion The concentrations of serum IL-6,IL-18,hs-CRP and TNF-αare significantly increased in AMI pa-tients treated with PCI.PCI operation may induce inflammatory reaction.High serum levels of peripheral inflamma-tory cytokines IL-6,IL-18,hs-CRP and TNF-αhave an important role in major adverse cardiac events(MACE)and short-term prognosis in the first AMI patients treated with successful primary PCI.关键词
急性心肌梗死/白细胞介素6/白细胞介素18/高敏C反应蛋白/肿瘤坏死因子-α/支架植入术Key words
acute myocardial infarction/interleukin-6/interleukin-18/high-sensitivity C-reactive protein/tumor necrosis factor-alpha/percutaneous coronary intervention分类
医药卫生引用本文复制引用
邹治国,刘和俊,周碧蓉..急性心梗患者介入前后血清炎性细胞因子水平变化与早期预后关系[J].安徽医科大学学报,2015,(11):1665-1668,1669,5.基金项目
安徽高校省级自然科学研究项目 （）
