安徽医科大学学报Issue(11)：1674-1676,3.
HIF-1α、Survivin 在非小细胞肺癌中的表达
The expression of HIF-1αand Survivin in human non-small cell lung cancer
摘要
Abstract
Objective To study the expression of hypoxia-inducible factor-1α(HIF-1α)and Survivin in human non-small cell lung cancer (NSCLC),and the relationship between such expression and clinicopathological features of NSCLC.Methods 52 cases of tissue specimen including NSCLC,neighboring noncancerous tissue were collect-ed.These specimens were detected by immunohistochemical methods.Results The expression of HIF-1αand Sur-vivin showed significant difference (P <0.01)between NSCLC tissues and neighboring noncancerous tissues.The positive rates of expression of HIF-1α,Survivin were correlated with the tumor differentiation degree,lymphnode metastasis and tumor stage(P <0.05),and significant and positive correlation was observed between the positiver-ate of expression of Survivin and HIF-1α(P <0.05).Conclusion The overexpression of HIF-1αand Survivin is found in NSCLC.Survivin and HIF-1αmay play a synergistic role in the genesis and progression of the malignan-cy,and there may be a certain synergy between Survivin in the process of tumor occurrence and development.关键词
缺氧诱导因子-1α/生存素/非小细胞肺癌Key words
HIF-1α/Survivin/non-small cell lung cancer分类
医药卫生引用本文复制引用
聂弘,高从荣,赵敏,王瑾,邹强,万军..HIF-1α、Survivin 在非小细胞肺癌中的表达[J].安徽医科大学学报,2015,(11):1674-1676,3.基金项目
安徽省自然科学基金 （）
