南方医科大学学报Issue(9)：1360-1361,1365,3.
海南汉族PLAG1基因rs6474051多态性与腮腺良性肿瘤的关联性
Association of pleomorphic adenoma gene 1 polymorphism and benign parotid tumor in Chinese Han population in Hainan Province
黄香 1邱勋定 2孙明磊 3何升腾1
作者信息
- 1. 海南省农垦三亚医院口腔科，海南 三亚 572000
- 2. 海南省人民医院口腔颌面外科，海南 海口 570311
- 3. 郑州大学第一附属医院口腔颌面外科，河南 郑州 450052
- 折叠
摘要
Abstract
Objective To investigate the relationship between rs6474051 polymorphism of pleomorphic adenoma gene 1 (PLAG1) and the benign parotid tumor in Chinese Han population in Hainan Province. Methods Sixty-five patients with benign parotid tumor and 69 healthy volunteers (control) were examined for Rs6474051 polymorphisms of PLAG1 gene by PCR and sequencing. Results Of the 65 patients with benign parotid tumor, the frequencies of CC, CT, and TT genotypes were 33 (50.8%), 25 (38.5%), and 7 (10.7%), as compared to those of 44 (63.8%), 24 (34.8%), and 1 (1.4%) in the control group (P=0.05). The allele frequency of C/T was 70%/30%in patients with benign parotid tumor, significantly different from that in the control group (80.6%/19.4%, P<0.05). Conclusion Rs6474051 polymorphism of PLAG1 gene may be associated with the benign parotid tumor in Chinese Han population in Hainan Province, and the T allele is probably one of susceptible genes.关键词
腮腺良性肿瘤/多形性腺瘤基因1/单核苷酸多态性rs6474051Key words
benign parotid tumor/pleomorphic adenoma gene 1/single nucleotide polymorphism/rs6474051引用本文复制引用
黄香,邱勋定,孙明磊,何升腾..海南汉族PLAG1基因rs6474051多态性与腮腺良性肿瘤的关联性[J].南方医科大学学报,2015,(9):1360-1361,1365,3.
