国际医药卫生导报2015，Vol.21Issue(17)：2588-2589,2591,3.DOI:10.3760/cma.j.issn.1007-1245.2015.17.029
替莫唑胺联合全脑放疗治疗非小细胞肺癌脑转移瘤的近期临床疗效观察
Temozolomide combined with whole-brain radiotherapy in treatment of non-small cell lung cancer complicated with metastatic brain tumor
杨宏山 1瞿广桥1
作者信息
- 1. 432000 华中科技大学同济医学院附属孝感医院肿瘤科
- 折叠
摘要
Abstract
Objective To observe the therapeutic effect and toxicity of temozolomide combined with whole-brain radiotherapy in the treatment of non-small cell lung cancer complicated with metastatic brain tumor.Methods 32 patients with non-small cell lung cancer who were diagnosed with brain metastases orally took temozolomide (75mg/m2·d) and received 40 Gy fractionated conventional external-beam radiotherapy (2 Gy per day,5 days per week) for 4 weeks.After radiotherapy,patients took temozolomide (200mg/m2·d) for 5 days every 4 weeks for 6 cycles.Progression-free survival curves and overall were estimated by Kaplan-Meier technique.Results All the 32 patients were evaluable for response with 5 cases of CR,19 PR,4 SD,and 4 PD.The overall response rate was 74.9％ and the clinical benefit rate was 87.4％.The median progression-free survival time was 7.6 months.The main side effects were gastrointestinal reaction and myelosuppression,which were alleviated by symptomatic treatment.Conclusions Temozolomide combined with whole-brain radiotherapy is effective with mild toxicity for patients with non-small cell lung cancer who were diagnosed with brain metastases.关键词
替莫唑胺/全脑放疗/非小细胞肺癌/脑转移瘤Key words
Temozolomide/Whole-brain radiotherapy/Non-small cell lung cancer/Brain metastases引用本文复制引用
杨宏山,瞿广桥..替莫唑胺联合全脑放疗治疗非小细胞肺癌脑转移瘤的近期临床疗效观察[J].国际医药卫生导报,2015,21(17):2588-2589,2591,3.
