国际病理科学与临床杂志Issue(9)：1677-1685,9.DOI:10.3978/j.issn.2095-6959.2015.09.020
整合子介导鲍曼不动杆菌耐药机制研究进展
Advance in mechanism of integron mediated antibiotic resistance among clinical isolates of Acinetobacter baumannii
摘要
Abstract
hTe resistance of Acinetobacter baumannii to a wide range of clinical antibiotics is a severe problem in China, especially the resistance rate of A. baumannii isolates to carbopenems has been increasing in recent 5 years. Making a further investigation on the reasons for the increasing rate of resistance and the epidemiological spread of drug-resistant strains contributes to controlling the severe situation of resistance. Integron, as a new mobile gene element, not only able to capture resistance genes to compose resistance gene cassettes, but also closely related to the horizontal transmission of resistance genes, which plays a lead role in mechanisms of resistance among clinical isolates of A. baumannii. hTis review emphasizes on the prevalence, characterization and effect of integrons among isolates of A. baumannii both in China and abroad.关键词
整合子/基因盒/鲍曼不动杆菌/耐药Key words
integron/gene cassette/acinetobacter baumannii/resistance引用本文复制引用
蔡蕊,秦婷婷(综述),顾兵,马萍(审校)..整合子介导鲍曼不动杆菌耐药机制研究进展[J].国际病理科学与临床杂志,2015,(9):1677-1685,9.基金项目
国家自然科学基金(81471994)，江苏省大学生创新创业训练计划项目(201510313009Z)。This work was supported by National Natural Science Foundation of China (81471994) and Training Program of Innovation and Entrepreneurship for Undergraduates of Jiangsu Province (201510313009Z), P. R. China （81471994）
