神经损伤与功能重建Issue(5)：399-402,405,5.DOI:10.3870/sjsscj.2015.05.007
脑微出血对急性脑梗死患者溶栓治疗后出血转化及功能预后的影响：一项 Meta 分析
Effect of Cerebral Microbleeds on Hemorrhagic Transformation and Function Prognosis in Pa-tients with Cerebral Infarction after Thrombolysis：a Meta-analysis
曹江慧 1刘广志 1周军 1李洁 2李小奇 1龙清云1
作者信息
- 1. 武汉大学中南医院放射科武汉 430071
- 2. 河北省石家庄市第一医院超声科石家庄 050011
- 折叠
摘要
Abstract
Objective: To evaluate the effects of cerebral microbleeds (CMBs) on hemorrhage transformation (HT) and function prognosis in patients with acute cerebral infarction after thrombolytic therapy. Methods: PubMed, El-sevier, CNKI, Wanfang and Weipu Databases were searched. Statistical analyses were performed by RevMan 5.2 software. Results: Eight studies (1 583 patients) were analyzed. Meta-analysis revealed the presence of microbleeds as an increased risk of HT and sICH (P=0.03;P=0.01). However, Meta-analysis of neurological functional outcome at three months revealed the presence of CMBs as a negative factor of favorable outcome (P=0.0002). When the cases with CMBs were classified into different groups depending on the number, the risk of HT and sICH increased with the number of CMBs. Patients with more than 10 CMBs showed an increased risk of HT and sICH when com-pared to those with less than 10 CMBs (P=0.03;P=0.04). Conclusion: There is an increased risk of HT and poor prognosis following thrombolysis for acute cerebral infarction patients with CMBs.关键词
微出血/急性脑梗死/溶栓治疗/出血转化/Meta 分析Key words
cerebral microbleeds/acute ischemic stroke/thrombolytic therapy/hemorrhagic transformation/Meta analysis分类
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曹江慧,刘广志,周军,李洁,李小奇,龙清云..脑微出血对急性脑梗死患者溶栓治疗后出血转化及功能预后的影响：一项 Meta 分析[J].神经损伤与功能重建,2015,(5):399-402,405,5.
