解放军医学院学报2015，Vol.36Issue(9)：911-915,939,6.DOI:10.3969/j.issn.2095-5227.2015.09.015
结直肠癌组织Endoglin标记的微血管密度与淋巴结及远处转移相关性的Meta分析
Meta analysis of correlation between microvessel density for endoglin and lymph node metastasis and distant metastasis in colorectal cancer
摘要
Abstract
Objective To investigate correlation between microvessel density (MVD) in endoglin (CD105) and lymph node metastasis, distant metastasis in the specimens of colorectal cancer.Methods Systematic searches of Wanfang, CNKI and cqvip databases meeting specified search criteria were performed from January 2000 to October 2014 with"colorectal cancer, colon cancer, rectal cancer, endoglin, CD105" as key words, and the data meeting the selected standard were collected, then Meta-analysis was carried out by Revman 5.3.Results Twelve researches about the correlation of MVD for endoglin and lymph node metastasis were selected based on the standard. There were 741 patients, including 373 patients with lymph node metastasis and 368 patients without lymph node metastasis. Heterogeneity was found in these reports (χ2=136.86,P<0.01,I2=92%). Random effects model was applied, and colorectal cancer tissues with or without lymph node metastasis were compared. The weighted mean difference (WMD) of MVD for endoglin was 9.89 (95%CI= 6.92 -12.85). The MVD for endoglin of colorectal cancer tissue with lymph node metastasis was significantly higher than that of colorectal cancer tissue without lymph node metastasis (Z=6.54,P<0.05). Six reports about the correlation of MVD for endoglin and distant metastasis were selected based on the standard. There were 305 patients, including 79 patients with distant metastasis and 226 patientswithout distant metastasis. Heterogeneity was found in these researches (χ2=77.28,P<0.01,I2=94%). Random effects model was applied, and colorectal cancer tissues with or without distant metastasis were compared. The WMD of MVD for endoglin was 7.9 (95%CI= 1.91-13.88). The MVD for endoglin of colorectal cancer tissue with distant metastasis was significantly higher than that of colorectal cancer tissue without distant metastasis (Z=2.59,P<0.05). Conclusion In colorectal cancer patients, higher MVD for endoglin is observed in cancer tissues with lymph node metastasis and distant metastasis in colorectal cancer patients. The detection of MVD for endoglin in colorectal cancer has great significance in screening patients with high risk of metastasis.关键词
结直肠肿瘤/Endoglin/淋巴结转移/远处转移/Meta分析Key words
colorectal neoplasms/endoglin/lymph node metastasis/distant metastasis/meta-analysis分类
医药卫生引用本文复制引用
樊银杰,王巍,过灵香,孙宏治..结直肠癌组织Endoglin标记的微血管密度与淋巴结及远处转移相关性的Meta分析[J].解放军医学院学报,2015,36(9):911-915,939,6.基金项目
吴阶平医学基金会临床科研专项资助基金(320.6750.1393) （320.6750.1393）
辽宁省科学技术计划项目(2013225305) （2013225305）
辽宁医学院校长基金—奥鸿博泽研究生科研创新基金(AH2014014) （AH2014014）
辽宁省工业企业科技特派员行动项目基金(20130106) Supported by the special funds of Wu Jie-ping medical foundation of clinical research (320.6750.1393) （20130106）
Science and Technology Plan Projects of Liaoning Province (2013225305) （2013225305）
Aohongboze Graduate Sci-tech Innovation Foundation, the President Fund of Liaoning Medical University(AH2014014) （AH2014014）
Industrial Enterprise Science and Technology Correspondent Action Plan Projects of Liaoning Province(20130106) （20130106）
