解放军医学院学报2015，Vol.36Issue(9)：916-919,4.DOI:10.3969/j.issn.2095-5227.2015.09.016
107例晚期喉癌患者放疗疗效分析
Locally advanced laryngeal cancer treated by radiotherapy: A survival analysis of 107 cases
摘要
Abstract
Objective To analyze the clinical results of 107 patients with locally advanced laryngeal cancer treated by radiotherapy in Chinese PLA General Hospital.Methods One hundred and seven newly diagnosed laryngeal cancer patients of stage Ⅲ or Ⅳ were treated with radiotherapy from May 2007 to April 2013. Three-dimensional conformal radiotherapy(3DCRT) (35.5%) and intensity modulated radiation therapy (IMRT)(64.5%) were used in the study. The prescription dose was 50-60 Gy to the high risk target and 44-54 Gy to the low risk target. Seventeen cases with no surgery and 10 cases of incomplete resection underwent radical radiotherapy. The prescription dose of residual tumor or metastatic lymph node target region was 64.5-70 Gy. Acute side-effects were evaluated following the established RTOG/EORTC criteria.Results The median follow up time was 31.8 months (range, 4 to 76 months). The incidence rate of skin toxicity, oral mucositis and esophagitis - tracheitis was 99.1%, 84.1% and 77.6%, respectively. Until May 2014, there were 32 cases had treatment failure and 26 casesdied. Of all the died patients, 23 died of tumor-related factors and 3 died of other factors. The local relapse-free survival (LRFS), regional relapse-free survival (RRFS), distant metastasis-free survival (MFS) and overall survival (OS) were 78.5%, 95.2%, 88.9% and 75.7% for 3 years. The clinical stage was an independent factor for the 3-year LRFS and tumor location could affect 3-year MFS, while the different surgical methods did not show influences on the survival.Conclusion Radical chemoradiotherapy is a good choice for patients unfit for surgery or be willing to reserving laryngeal function and salvage surgery is effective for the failure cases.关键词
喉癌/放疗/生存率Key words
laryngeal cancer/radiotherapy/survival分类
医药卫生引用本文复制引用
杜镭,马林,冯林春,曲宝林,王发鹏,曾铭玥,杨微..107例晚期喉癌患者放疗疗效分析[J].解放军医学院学报,2015,36(9):916-919,4.基金项目
解放军总医院苗圃基金(14KMM34) （14KMM34）
