摘要
Abstract
Objective To investigate influence of serum cholesterol on the activity level of Lp‐PLA2 in the pa‐tients with coronary heart disease(CHD) .Methods 61 patients with hypercholesterolemia(group Ⅰ ) ,61 patients with CHD(group Ⅱ ) ,61 patients with CHD complicating hypercholesterolemia(group III ) and 61 healthy persons of healthy physical examination(control group) were selected .Blood lipid indexes and related biochemical indexes were compared among various groups .The correlation between Lp‐PLA2 with the related indexes was analyzed .Results The levels of TC ,TG ,LDL‐C ,hs‐CRP ,Lp‐PLA2 ,CysC and Hcy in the group III were significantly higher than those in the control group ,group I and II ,while the HDL‐C level was significantly lower than that in the control group , group I and II .The levels of TC ,HDL‐C ,LDL‐C and Lp‐PLA2 in the group II were significantly lower than those in the control group ,while the levels of TG ,hs‐CRP ,CysC and Hcy were significantly higher than those in the control group ,the levels of TC ,TG ,LDL‐C ,hs‐CRP ,Lp‐PLA2 ,CysC and Hcy were significantly lower than those in the group I ,the HDL‐C level was significantly higher than that in the group I .The levels of TC ,TG ,LDL‐C ,hs‐CRP ,Lp‐PLA2 ,CysC and Hcy in the group I were significantly higher than those in the control group ,while the HDL‐C level was significantly lower than that in the control group(P < 0 .05) .Lp‐PLA2 had a positive correlation with TC and LDL‐C .Conclusion Serum cholesterol has significant influence on the activity level of Lp‐PLA2 in the patients with CHD ,which can significantly improve its biological activity .关键词
冠心病/胆固醇/脂蛋白相关磷脂酶A2Key words
coronary heart disease/cholesterol/Lp-PLA2
