摘要
Abstract
Objective To evaluate the effectiveness and safety of different doses of calcitriol combined with he‐modiafiltration in treating renal osteodystrophy .Methods 35 cases of renal osteodystrophy in our hospital were cho‐sen as the research subjects and divided into the control group and the experimental group .The control group were treated with high dose of calcitriol(1 .0 μg) combined with hemodiafiltration ,while the experimental group adopted low dose of calcitriol(0 .5 μg) combined with hemodiafiltration .The indices of renal function ,iPT H ,BAP ,serum lev‐els of calcium and phosphorus and the improvement situation of clinical symptoms after 16‐week treatment were com‐pared between the two groups .Results The symptom scores of two group after treatment were significantly de‐creased compared with before treatment ,the difference had statistical significance(P< 0 .05) ,but there was no statis‐tically significant difference between the two groups(P> 0 .05) .The iPT H ,product of calcium and phosphorus ,ser‐um levels of calcium and phosphorus in the two group were improved after treatment ,the iPT H level of the experi‐mental group was higher than that of the control group ,the product of calcium and phosphorus ,and serum phosphor‐us level were lower than those in the control group ,the differences were statistically significant(P< 0 .05) .BAP of the two group were decreased after treatment ,but the decrease in the control group was more obvious ,the difference compared with the experimental group had statistical significance(P< 0 .05) .ALB ,BUN and SCr after treatment in the two group had no obvious improvement ,the differences between groups were not statistically significant (P>0 .05) .Conclusion In the combination with hemodiafiltration for treating renal osteodystrophy ,low dose of calcitriol can achieve the same effect as high dose ,but has much less adverse reactions and better safety .关键词
剂量/盖三淳/血液透析滤过/肾性骨营养不良Key words
dosage/calcitriol/hemodiafiltration/renal osteodystrophy
