检验医学与临床Issue(19)：2890-2891,2894,3.DOI:10.3969/j.issn.1672-9455.2015.19.031
肾脏移植患者中厄他培南和他克莫司的药物相互作用研究
Interaction influence of two drugs after simultaneously taking tacrolimus and ertapenem in renal transplant patients
朱春丽 1吴家清 1李琴 1刘东 1周结学 1蒙善东 1申升 1郑克立1
作者信息
- 1. 广东省第二人民医院器官移植科，广州 510317
- 折叠
摘要
Abstract
Objective To observe the interaction of tacrolimus(FK‐506) and ertapenem after simultaneously taking in renal transplant recipients of Guangdong region .Methods Twelve renal transplant recipients in our hospital during 2013 were retrospectively evaluated .The blood drug concentrations of tacrolimus and ertapenem were detected by using the automatic chemoluminescence immunoassay .Results The blood concentration of tacrolimus on 3 d after taking was increased from(7 .5 ± 0 .34)ng/mL to(13 .8 ± 0 .25)ng/mL(P< 0 .05) .The fraction derived from the drug interaction potential scale indicated that certain mechanism of interaction action and influence of ertapenem and ta‐crolimus existed in the patient′s body .Conclusion In simultaneously using tacrolimus (FK‐506) and ertapenem for kidney transplant patients ,the tacrolimus dose should be timely adjusted for preventing the drug poisoning .关键词
肾移植/厄他培南/他克莫司Key words
renal transplant/tacrolimus/ertapenem引用本文复制引用
朱春丽,吴家清,李琴,刘东,周结学,蒙善东,申升,郑克立..肾脏移植患者中厄他培南和他克莫司的药物相互作用研究[J].检验医学与临床,2015,(19):2890-2891,2894,3.
