临床与实验病理学杂志Issue(8)：864-868,5.DOI:10.13315/j.cnki.cjcep.2015.08.006
肾脏原发性淋巴瘤19例临床病理分析
Primary renal lymphoma:a clinicopathological study of 19 cases
刘芳 1王璇 2王建军 1涂频 1程凯 1陆珍凤 1余波 1饶秋1
作者信息
- 1. 南京大学医学院临床学院/南京军区南京总医院病理科，南京 210002
- 2. 江苏省徐州市中心医院病理科，徐州 221009
- 折叠
摘要
Abstract
Purpose To investigate the clinicopathological and immunohistochemical features of primary renal lymphomas ( PRL) , and to discuss the diagnosis, differential diagnosis, treatment and prognosis of the tumors. Methods Clinical data of 19 patients with PRL from January 2005 to October 2014 were retrospectively analyzed. Result The 19 patients in this study, there were 11 males and 8 females and the age ranged from 37 to 85 years old (averaged 55). Patients were mainly presented with unilateral renal masses, with lumbodynia as the main symptom. 13 patients underwent nephrectomy, 6 patients underwent renal biopsy and 17 patients received CHOP or R-CHOP chemotherapy. All of them were diagnosed as non-Hodgkin’ s lymphoma, with 14 cases of diffuse large B cell lym-phoma (DLBCL) (73. 684%, 14/19), 4 cases of B cell small cell lymphoma (21. 053%, 4/19), and 1 cases of T cell lymphoma (5. 263%, 1/19). Follow-up information was available in 15 patients. 12 were still alive and survived for 1~78 months, while the other 3 were dead with 1 case who died of cerebral infarction, and survived for 3~38 months ( averaged 23 months) . Conclusion PRL is an extranodal lymphoma which is rare in kidney and is often misdiagnosed as renal carcinomas due to its nonspecific clinical manifestations. The diagnosis of PRL can be confirmed by histopathological examination, immunohistochemistry and molecular analy-sis. The majority of the lymphomas are B cell lymphomas and most of them are DLBCL. The recommended treatment is surgery com-bined with chemotherapy and the prognosis is associated with the age, clinicopathological characteristics, tumor types and treatment.关键词
肾脏肿瘤/原发性淋巴瘤/免疫表型/临床特征/治疗方式/预后Key words
renal neoplasms/primary lymphoma/immunohistochemical features/clinical characteristics/treatment/prognosis分类
医药卫生引用本文复制引用
刘芳,王璇,王建军,涂频,程凯,陆珍凤,余波,饶秋..肾脏原发性淋巴瘤19例临床病理分析[J].临床与实验病理学杂志,2015,(8):864-868,5.
