临床与实验病理学杂志Issue(8)：869-872,4.DOI:10.13315/j.cnki.cjcep.2015.08.007
结直肠癌中 K-ras基因突变与 Fascin-1蛋白表达的相关性
Correlation between mutation of K-ras and expression of Fascin-1 in colorectal cancer tissue
摘要
Abstract
Purpose To observe the mutation of K-ras gene and expression of Fascin-1 protein in CRC tissues and their relationship with clinical pathological features, and then to analyze the correlation between mutation of K-ras and expression of Fascin-1. Methods In 86 cases of CRC tissues, K-ras mutation was detected by DNA sequencing analysis, and Fascin-1 expression was detected by im-munohistochemical method. Results In CRC tissues the mutation rate of K-ras was 34. 88%, the expression rate of Fascin-1 was 60. 47%. The mutation rate of K-ras in lymph node metastasis group was higher than that of without lymph node metastasis group, and that in distant metastasis group was higher than that of without distant metastasis group(P<0. 05). The expression rate of Fascin-1 in serosa invasion group was higher than that of without serosa invasion group, and that in lymph node metastasis group was higher than that of without lymph node metastasis group, and that in distant metastasis group was higher than that of without distant metastasis group (P<0. 01). There was a correlation between the mutation of K-ras gene and the expression of Fascin-1 in CRC tissues (rp =0. 236, P<0. 05). Conclusions The CRC tissues with mutation of K-ras are more likely to metastasize and the CRC tissues with expression of Fascin-1 are more likely to invade serosa and metastasize. The CRC tissues with mutation of K-ras are more likely to express Fascin-1.关键词
结直肠肿瘤/K-ras/Fascin-1/免疫组织化学Key words
colorectal neoplasms/K-ras/Fascin-1/immunocytochemistry分类
医药卫生引用本文复制引用
李晟,蔡琳,刘启玲,周伊,张润岐..结直肠癌中 K-ras基因突变与 Fascin-1蛋白表达的相关性[J].临床与实验病理学杂志,2015,(8):869-872,4.基金项目
陕西省教育厅科研计划项目(11JK0714)、西安医学院校级科研基金扶植项目(2011FZ03) （11JK0714）
