临床与实验病理学杂志Issue(9)：1001-1004,4.DOI:10.13315/j.cnki.cjcep.2015.09.009
子宫颈鳞状细胞癌中Galectin-7表达与HPV 16感染的相关性
Expression of Galectin-7 in squamous cell carcinoma of the cervix and its association with HPV 16 infection
摘要
Abstract
Purpose To study the expression of Galectin-7 in squamous carcinoma of the cervix and its correlation with HPV 16 infec-tion in Uyghur and Han women. Methods The expression of Galectin-7 in paraffin-embedded cervical tissues collected from Uyghur women including 21 patients with cervicitis and 49 patients with squamous carcinoma of the cervix and Han women including 25 patients with cervicitis and 29 patients with squamous cervical cancer was evaluated by immunohistochemical SP method. The infection of HPV 16 was evaluated by PCR amplification of HPV DNA from the corresponding cervical tissue samples. The expression of levels of Galec-tin-7 in cervical tissues was analyzed according to the corresponding integrated optical density ( IOD) value of Galectin-7 in cervical le-sions with professional image analysis software Image-Pro Plus (IPP) 6. 0. Results PCR detection of HPV 16 in Uyghur patients from Kashghar showed that 20 patients were positive and 29 cases were negative for HPV 16 in squamous cervical cancer patients whereas in patients with cervicitis, only 5 cases were positive, 16 cases were negative for HPV 16. Furthermore the detection of HPV 16 in Han patients showed that 2 cases were positive and 27 cases was negative in patients with squamous cervical cancer patients, and all the ca-ses were negative for HPV 16 in patients with cervicitis. The expression of Galectin-7 in squamous cervical cancer tissues was signifi-cantly lower than that in the cervicitis patients (P<0. 05). The expression of Galectin-7 in HPV 16 positive squamous cervical cancer patients was significantly lower than that in HPV 16 negative patients ( P<0. 05 ) . There was no obvious correlation between the ex-pression levels of Galectin-7 in squamous cervical cancer patients with the differentiation degree and disease oneset age both in Uyghur and Han patients. Conclusion Compared with cervicitis tissues, Galectin-7 expression in squamous cervical cancer is down-regulated in Uyghur women from Kashghar region implying that the expression of Galectin-7 may play a certain role in the occurrence and develop-ment of squamous cervical cancer, and its detection has a certain reference value for the diagnosis of cervical cancer for Uyghur women.关键词
子宫颈肿瘤/鳞状细胞癌/Galectin-7/HPV 16/分化程度/发病年龄Key words
cervical neoplasm/squamous cell cancer/Galectin-7/HPV 16/differentiation degree/oneset age分类
医药卫生引用本文复制引用
贾索尔·肖克热提,阿力甫江·海力力,阿力木·伊力亚斯,海米提·阿布都力木..子宫颈鳞状细胞癌中Galectin-7表达与HPV 16感染的相关性[J].临床与实验病理学杂志,2015,(9):1001-1004,4.基金项目
国家级大学生创新项目(CX2013012) （CX2013012）
