临床与实验病理学杂志Issue(9)：1009-1012,4.DOI:10.13315/j.cnki.cjcep.2015.09.011
结肠癌组织中OTUB1的表达及其临床意义
Expression of OTUB1 in colon cancer and its clinical significance
摘要
Abstract
Purpose To investigate the expression of OTUB1 in colon cancer and the relationship between its expression and some clinicopathologic parameters. Methods Quantitative real-time PCR and immunohistochemical SP method were carried out in selected colon cancer and normal mucosa tissues. Results OTUB1 mRNA in colon cancer was 3. 5-fold higher than the normal mucosa. The expression of OTUB1 protein in the colon cancer was significantly higher than normal mucosa (P<0. 05). Moreover, its expression in normal tissues, adenoma and colon cancer showed a gradually increasing trend (P<0. 05). The higher expression of OTUB1 in colon cancer was related with tumor size, differentiation and lymph node metastasis. Conclusions OTUB1 may play an important role in co-lon cancer development.关键词
结肠肿瘤/OTUB1/实时定量PCR/免疫组织化学Key words
colon neoplasm/OTUB1/quantitative real-time PCR/immunohistochemistry分类
医药卫生引用本文复制引用
姜维娜,黄维清,刘鑫,刘红云,孔庆暖,韩增磊,陈桦..结肠癌组织中OTUB1的表达及其临床意义[J].临床与实验病理学杂志,2015,(9):1009-1012,4.基金项目
青岛市产学研合作计划[12-1-4-16-(3)-jch] （3）
