临床与实验病理学杂志Issue(9)：1013-1016,4.DOI:10.13315/j.cnki.cjcep.2015.09.012
早期喉癌CO2激光切除术后复发患者相关蛋白的表达
Expression of related proteins in early laryngeal squamous cell carcinoma patients with recur-rence after CO2 laser resection
孙玉满 1梁振 2吴蒙 1杨俊泉 3刘宏侠1
作者信息
- 1. 唐山市协和医院病理科 063004
- 2. 唐山市协和医院耳鼻咽喉头颈外科 063004
- 3. 唐山市人民医院放化疗科 063001
- 折叠
摘要
Abstract
Purpose To compare the therapeutic effects of CO2 laser resection and traditional split laryngeal surgery on the early laryn-geal cancer, and to examine relationship between the expression of p27 and PTEN and clinical prognosis in early laryngeal squamous cell carcinoma. Methods 85 patients who underwent CO2 laser resection surgery and 46 patients who underwent split laryngeal surger-y were selected and the occurrence rates after surgery were observed. SP immunohistochemical method was uesd to detect the expression of p27 and PTEN in tumor resection marginal and their surgical margine tissues. Clinical data were collected and all patients were fol-lowed up. Results In the more than two-year follow-up study, 14 of 85 patients in CO2 laser treatment group ( recurrent group) pres-ented with local recurrence and the recurrence rate was 16. 5%, while 6 of 46 patients in split laryngeal surgery group presented with local recurrence and the recurrent rate was 13. 0%. There was no statistical significance in recurrence rate between the two groups ( P> 0. 05). 10 of all the none recurrent patients did not follow the doctor’s advice to quit smoking after the operation, while 12 in the recurrent patients did not, the difference between the two groups was statistically significant (P<0. 01). The positive rate of p27 and PTEN in laryngeal carcinoma tissues and the cancer adjacent tissues ( negative surgical margin tissues ) was 43. 5% ( 57/131 ) , 80. 2% (105/131) and 48. 9% (64/131), 83. 2% (109/131), respectively, with a significant difference (P<0. 01). The positive rate of p27 and PTEN in laryngeal carcinoma tissues of the recurrent group and non recurrent group was 20. 0% (4/20), 47. 7% (53/111) and 10. 0% (2/20), 55. 9% (62/111), respectively, with a significant difference (P<0. 05). While the positive rate of p27 and PTEN in tumor resection marginal tissues of the recurrence group and non recurrence group was 50. 0% ( 10/20 ) , 85. 6% ( 95/111) and 40. 0% (8/20), 91. 0% (101/111), the difference was also statistically significant (P<0. 01). Conclusions There was no statistically significant difference in tumor recurrence rate between CO2 laser surgery and traditional split laryngeal surgery. Postoper-ative recurrence is closely related to resume smoking. The recurrence rate of p27 and/or PTEN negative patients was higher than that of the opposite ones which should be followed up closely after treatment.关键词
声带肿瘤/早期/CO2激光切除术/p27/PTEN/复发Key words
vocal cord neoplasm/early stage/CO2 laser resection/p27/PTEN/recurrence分类
医药卫生引用本文复制引用
孙玉满,梁振,吴蒙,杨俊泉,刘宏侠..早期喉癌CO2激光切除术后复发患者相关蛋白的表达[J].临床与实验病理学杂志,2015,(9):1013-1016,4.
