国际眼科杂志Issue(9)：1621-1624,4.DOI:10.3980/j.issn.1672-5123.2015.9.36
OCT和视野对颅咽管瘤患者视功能损伤的评价
Assessment of visual function by optical coherence tomography and visual field for craniopharyngioma patients
摘要
Abstract
AIM: To analyze the differences and correlations between ganglion cell complex ( GCC ) , peripapillary retinal nerve fiber layer ( pRNFL) and mean defect ( MD) , mean sensitivity ( MS ) of visual field ( VF ) in craniopharyngioma patients, to evaluate the feasibility of optical coherence tomography ( OCT) in diagnosis of the visual pathway damage of craniopharyngioma patients.METHODS: Ninety - five craniopharyngioma patients treated in Beijing Tiantan Hospital, from September 2014 to April 2015 received the VF test by Octopus 900 automated perimeter with the central 30 degree program and the mean thickness measurements of GCC and pRNFL by RTVue OCT. Spearman rank correlation coefficient ( rs ) was used to assess the correlation between GCC, pRNFL and MD, MS. The changes of VF and optic disc were analyzed. <br> RESULTS:Abnormal pRNFL findings occurred in 53. 1%(93/175), which included optic disk edema 3. 4% (6/175), atrophic changes of optic nerve 47. 4% ( 83/175 ) and glaucoma-like optic neuropathy 7. 4% (13/175). Various visual field defect was 71. 4% ( 125/175 ). The average thickness of binocular pRNFL (rsOD=-0.411, rsOS=-0.354) and GCC (rsOD=-0.400, rsOS=-0.314) had correlation with MD (P<0. 01). The average thickness of pRNFL (rsOD =0.412, rsOS=0. 342) and GCC (rsOD=0. 414, rsOS=0. 299) had correlation with MS (P<0. 01). <br> CONCLUSION: The average thickness of pRNFL and GCC has correlation with VF damage, can evaluate the optic nerve damage of craniopharyngioma patients quantitatively. The thinner the thickness of pRNFL and GCC is, the serious damage of visual function is. During the clinical work, visual field test combined with OCT are helpful to find and assess the damage of visual pathway and prognosis.关键词
颅咽管瘤/视野损害/神经节细胞复合体/神经纤维层/相关性Key words
craniopharyngioma/vision field damage/ganglion cell complex/peripapillary retinal nerve fiber layer/correlation引用本文复制引用
汤洋,王梅子,瞿远珍,杨柳,方民,孟蕾,王丽娜,雷鹍,王淑然,陆雯..OCT和视野对颅咽管瘤患者视功能损伤的评价[J].国际眼科杂志,2015,(9):1621-1624,4.基金项目
北京市卫生系统高层次卫生技术人才培养计划项目(No.2013-03-051) （No.2013-03-051）
