国际眼科杂志Issue(10)：1684-1690,7.DOI:10.3980/j.issn.1672-5123.2015.10.03
激素性高眼压对LASIK术后患者视功能影响的初步研究
Effects of steroid induced ocular hypertension on visual performance in post - LASIK patients：preliminary evidence
摘要
Abstract
AIM: To investigate the effect of intraocular pressure ( IOP ) fluctuations on the visual performance in steroid responders after laser in situ keratomileusis ( LASIK) . <br> METHODS:Fifteen post-LASIK patients who underwent steroid-induced IOP fluctuations were enrolled as study group. And all received effective therapy when identified. Another 15 matched post-LASIK patients who used topical steroids for the same duration without developing hypertension were selected as control group. During the follow - up visits, uncorrected distant visual acuity ( UDVA ) , photopic contrast sensitivity, wavefront aberrations, and corneal topography, were measured. These aimed at comparing the differences in postoperative changes between the groups. <br> RESULTS: In study group, comparison of preoperative and postoperative IOP, the amplitude of abnormal IOP fluctuations reached 10. 6±4. 4mmHg (ranged from 21. 3 to 32. 9mmHg ). Compared with postoperative ocular hypertension, statistics demonstrated significant changes such as UDVA, photopic contrast sensitivity, and wavefront aberrations, and corneal topography under the condition of normal tension. 1 ) UDVA: a significant difference was seen in UDVA between ocular hypertension and normal tension ( P<0. 001 ); 2 ) Contrast sensitivity:results showed significant differences in 3, 6, 12, and 18 cycles/degree of photopic contrast sensitivity ( all P <0.05 ); 3 ) Wavefront aberrations: statistics indicated significant differences in higher order aberrations ( HOA) , trefoil and spherical aberration ( P< 0. 05 for all ); 4 ) Corneal topography parameters such as Q - value, difference value ( Diff - value ) between the posterior corneal surface and the best fit sphere in the central region (Ф=6mm), and central corneal thickness (CCT) showed significant differences (P<0. 01 for all). However, in control group, except for the increased CCT with time, no other significant changes were observed during the follow-up visits. <br> CONCLUSION: Transient abnormal IOP fluctuations might induce remarkable optical and visual changes, and limiting the IOP fluctuations might improve the visual performance in steroid responders after LASIK.关键词
眼压/裸眼远视力/对比敏感度/波前像差/角膜地形图Key words
intraocular pressure/uncorrected distant visual acuity/contrast sensitivity/wavefront aberrations/corneal topography引用本文复制引用
赵武校,林恩韦,刘洪婷,蓝方方,刘伟民,黄建忠..激素性高眼压对LASIK术后患者视功能影响的初步研究[J].国际眼科杂志,2015,(10):1684-1690,7.基金项目
Supported in part by Health Bureau of Guangxi Zhuang Autonomous Region, Nanning, China ( No:Z2010242) （ No:Z2010242）
