国际眼科杂志Issue(10)：1705-1708,4.DOI:10.3980/j.issn.1672-5123.2015.10.07
不同浓度玻璃酸钠对新西兰兔干眼眼表变化的影响
Effect of different concentrations of sodium hyaluronate on the ocular surface change of dry eye in New Zealand rabbits
王双勇 1田英 2程燕 1朱海峰 1吴洁2
作者信息
- 1. 710002 中国陕西省西安市第一医院眼科
- 2. 710002 中国陕西省西安市，陕西省眼科研究所 陕西省眼科学重点实验室
- 折叠
摘要
Abstract
AIM:To observe the effect of different concentrations of sodium hyaluronate on ocular surface change of dry eye.METHODS: New Zealand rabbits with dry eye was prepared and treated with 0. 1% and 0. 3% sodium hyaluronate drops fluid respectively, which were regarded as low concentration treatment group ( group B) and high concentration treatment group ( group C ) respectively. However, the rabbits treated with saline were regarded as control group ( group A ) . And then, corneal fluorescein staining, Schirmer test, conjunctival goblet cells, mucin expression and histological changes were observed. <br> RESULTS: On D7 and D14 after treatment, corneal fluorescein staining scores were lower in group B and group C than that in group A ( P<0. 05 ). However, Schirmer test, goblet cell density and mucin content were higher in group B and group C than those in A group (P <0. 05). Tear secretion and goblet cell density were higher in Group C than those in group B (P<0. 05). Compared with group B and group C, the thicknesses of corneal and conjunctival epithelial cell layer were thinner in group A. There were not obvious abnormalities in corneal and conjunctival stroma in each group. <br> CONCLUSION: The sodium hyaluronate can improve ocular surface damage of dry eye in New Zealand rabbits. The high concentration of sodium hyaluronate has better effect than low concentration.关键词
玻璃酸钠/干眼/眼表损害Key words
sodium hyaluronate/dry eye/ocular damage引用本文复制引用
王双勇,田英,程燕,朱海峰,吴洁..不同浓度玻璃酸钠对新西兰兔干眼眼表变化的影响[J].国际眼科杂志,2015,(10):1705-1708,4.
