中国伤残医学Issue(17)：30-32,3.DOI:10.13214/j.cnki.cjotadm.2015.17.021
丰富康复环境对慢性脑缺血大鼠学习记忆的影响
The Effect of Enriched Rehabilitative Environment Intervention on Learning-memory in Chronic Cerebral Ischemia Rats
摘要
Abstract
Objective:To study the effects of enriched rehabilitative training on cognitive impairment in rats after chronic cerebral is-chemia.Methods:We choose healthy、male Wistar rats and adopted the long-term ligation of bilateral common carotid arteries to pro-duce the chronic cerebral ischemia model of rats that was similar to the human chronic cerebral ischemia.Rats were divided into normal group( NG) , standard environment( SE) and enriched environment( EE) .Within 2 days after surgery, EE rats were assigned to enriched environment housing, NG and SE rats were assigned to standard condition.The learning and memory ability was evaluated by Morris water maze after behavioral training at 1 days 4 days 7 days and 10days.Results:The escape latency and swim distance for searching the hidden platform were obviously longer in model group in comparison with normal group.The escape latency and swim distance for searching the moving platform were obviously longer in model group in comparison with normal group(P<0.01 or P<O.05).After enriched rehabilita-tive environment intervention, the escape latency and swim distance for searching the hidden platform were obviously shorter in EE group in comparison with standard environment(SE) group.(P<0.01或P<0.05) Conclusion: Enriched rehabilitative intervention can im-prove the ability of learning-memory.关键词
慢性脑缺血/丰富康复环境/学习记忆Key words
Chronic cerebral ischemia/Enriched rehabilitative environment/Learning -memory分类
医药卫生引用本文复制引用
彭博,裴文斌,张晓明..丰富康复环境对慢性脑缺血大鼠学习记忆的影响[J].中国伤残医学,2015,(17):30-32,3.基金项目
滨州医学院大学生科技创新活动基金项目 （）
