中国康复理论与实践Issue(9)：1058-1063,6.DOI:10.3969/j.issn.1006-9771.2015.09.016
脑卒中后上肢运动功能恢复大脑可塑性的磁共振弥散张量成像研究
Brain Plasticity of Upper Extremity Motor Function Recovery after Stroke:A Diffusion Tensor Imaging Study
摘要
Abstract
Objective To explore brain plasticity of upper extremities motor function recovery after stroke with diffusion tensor imaging (DTI). Methods 25 stroke patients with internal capsule lesions and affected corticospinal tract (CST), 4-8 weeks after onset, were divided randomly into rehabilitation group (n=13) and control group (n=12). Both groups received routine medication and the rehabilitation group al-so received rehabilitation. All the patients were scanned with DTI and assessed with upper extremity Fugl-Myer Assessment (UE-FMA) be-fore and 3 months after treatment. The fractional anisotropy (FA), FA ratio (rFA) and FA asymmetry (FAasy) in cerebral peduncle, posterior limb of internal capsule (PLIC) and corona radiate were obtained. The bilateral corticospinal tracts were reconstructed with diffusion tensor tractography. Results The scores of UE-FMA increased in both groups after treatment (P<0.05), and increased more in the rehabilitation group than in the control group (P<0.05). There was significant difference in FA, rFA and FAasy in the corona radiate section of CST after treatment in the rehabilitation group (P<0.05), but was not in the cerebral peduncle and PLIC section. However, there was no significant dif-ferences in FA, rFA and FAasy in the control group. The ipsilesional CST fibers were more compact after treatment in the rehabilitation group. Conclusion Rehabilitation can improve the upper extremities function recovery after stroke, which may associated with the repair-ment of CST in the corona radiate section.关键词
脑卒中/上肢/运动功能/弥散张量成像/磁共振成像/康复/大脑可塑性Key words
stroke/upper extremities/motor function/diffusion tensor imaging/magnetic resonance imaging/rehabilitation/brain plas-ticity分类
医药卫生引用本文复制引用
凌晴,林丽萍,胡世红,何嫱,许佳..脑卒中后上肢运动功能恢复大脑可塑性的磁共振弥散张量成像研究[J].中国康复理论与实践,2015,(9):1058-1063,6.基金项目
上海市闵行区卫生和计划生育委员会科研课题(No.2013MW07)。 （No.2013MW07）
