摘要
Abstract
Objective To observe the clinical effect and safety of baclofen for treating children with refractory gastroesoPhageal reflux in-duced cough. Methods 80 cases of refractory gastroesoPhageal reflux induced cough in the hosPital were randomly selected and divided into the observation grouP and the control grouP,40 cases in each grouP. Both grouPs were guided to adjust the way of life. The control grouP was treated with DomPeridone Tablets [ 0. 3 mg/ ( kg · time ) ,3 times/d ] ,OmePrazole Magnesium Enteric-Coated Tablets (20 mg/time,1 time/d). The observation grouP received baclofen tablets[0. 25 mg/ (kg·time),4 times/d] on the basis of the control grouP. The two grouPs were treated for 8 weeks. Observe and record the changes of cough,acid regurgitation,retrosternal burning sen-sation,and belching and other clinical symPtoms in the Patients during the treatment,and evaluate the scores of the clinical symPtom severity and symPtom frequency before treatment and after treatment. Observe the Patients before and after treatment. The changes of blood routine,liver and kidney function and adverse reaction were recorded before and after treatment. Results After treatment,the clin-ical efficacy of the observation grouP was 92. 50%,which was significantly higher than 67. 50% of the control grouP,the difference was statistically significant ( P < 0. 05 ) . ComPared with before treatment,the symPtom score and total score of symPtoms in the two grouPs were decreased,the difference is statistically significant ( P < 0. 05 ) and the observation grouP decreased more significantly,with signifi-cant difference ( P < 0. 05 ) . The incidence rate of adverse reactions in the observation grouP was 22. 50% which was obviously higher than 7. 50% in the control grouP ( P < 0. 05 ) ,and the adverse reactions were tolerable. The two grouPs before and after medication in children,the changes of blood routine,liver and kidney function changes were not found in the two grouPs. Conclusion Baclofen can be effective in the treatment of children with refractory gastroesoPhageal reflux cough,although there is a certain degree of drowsiness, fatigue,and other adverse reactions,but can really imProve the children's clinical symPtoms,and can be an additional treatment when the anti acid treatment can not achireve comPlete remission of symPtoms in children.关键词
巴氯芬/儿童/难治性胃食管反流性咳嗽/临床疗效/安全性Key words
baclofen/children/refractory gastroesoPhageal reflux induced cough/clinical effcacy/safety分类
医药卫生
