中国药业Issue(18)：17-18,19,3.
活化凝血时间监测对心脏瓣膜置换术患者低分子肝素剂量及伤口引流量的影响
Influence of Activated Coagulation Time Monitoring on Low Molecular Weight Heparin Dosage and Wound Drainage of Patients after Cardiac Valve Replacement
摘要
Abstract
Objective To investigate the influence of activated coagulation time (ACT) monitoring on the low molecular weight heparin dosage and wound drainage after cardiac valve replacement. Methods 100 cases of patients with cardiac valve replacement surgery un-der extracorporeal circulation in the hospital were randomly divided into the control group and the observation group,50 cases in each group. The two groups were given low molecular weight heparin;the observation group performed ACT,and the control group did not perform ACT. Results 10 h after operation,the amount of suspended red blood cells in the observation group were significantly lower than those in the control group( P ﹤ 0. 05). PT was significantly longer in the two groups than before operation,but with no statistical difference between the two groups( P ﹥ 0. 05);APTT was significantly longer in the control group( P ﹤ 0. 05),and had no obvious change in the observation group( P ﹥ 0. 05),the control group was obviously longer than the observation group( P ﹤ 0. 05). 24 h after operation,the PT in the two groups had no obvious difference compared with before,but APTT in the control group was still longer than before( P ﹤ 0. 05),and significantly longer than the observation group( P ﹤ 0. 05);the incidence rate of adverse reactions in the control group was significantly higher than that in the observation group( P ﹤ 0. 05). Conclusion ACT monitoring after cardiac valve replacement under extracorporeal circulation can adjust the dosage of low molecular weight heparin,is conducive to reducing the average wound drainage and suspended red blood cell input,while also reducing the occurrence of fluctuations in indicators such as APTT and adverse reactions such as bleeding,and is worth of clinical promotion.关键词
心脏瓣膜置换术/体外循环/低分子肝素/活化凝血时间/引流量Key words
cardiac valve replacement/extracorporeal circulation/low molecular weight heparin/activated coagulation time/drainage分类
医药卫生引用本文复制引用
冯润光,侯萍,刘莉,李金钟,李金玲..活化凝血时间监测对心脏瓣膜置换术患者低分子肝素剂量及伤口引流量的影响[J].中国药业,2015,(18):17-18,19,3.基金项目
河北省秦皇岛市科学技术研究与发展计划项目，项目编号201302A090。 （）
