中国药业Issue(18)：37-38,39,3.
依那西普治疗强直性脊柱炎60例疗效评价
Clinical Efficacy of Etanercept for Treating Ankylosing Spondylitis in 60 Cases
江仁奇 1张育民 1王军 1张聪明 1王军伟 1秦四清 1马涛1
作者信息
- 1. 西安交通大学医学院附属红会医院，陕西 西安 710054
- 折叠
摘要
Abstract
Objective To investigate the clinical efficacy of etanercept combined with total hip replacement in treating ankylosing spondylitis with hip flexion stiffness. Methods Totally 120 patients the hospital were selected and randomly divided into the observation group and the control group,60 cases in each group. The two groups were treated with total hip replacement,and received anti infec-tion,nutritional support,and anticoagulant drugs. On this basis,the observation group was added with etanercept(subcutaneous injection of 25 mg/time,2 times/week) for 12 weeks. The clinical symptoms and signs were observed before and after 4,8 and 12 weeks. The changes of BASDAI,BASFI,VAS,and PGA of the two groups were evaluated;the activity of hip joint,ESR,CRP were measured and recorded before and after surgery. Results After 8 weeks of treatment,the improvement rate of ASAS 20 and ASAS 50 in the observa-tion group were significantly higher than those in control group( P ﹤ 0. 05);the improvement rate of ASAS 20 after 12 weeks in the two groups was 100. 00%,and the improvement rate of ASAS 50 in the observation group was 93. 33%,which was significantly higher than 81. 67% in the control group( P ﹤ 0. 05);the total VAS score and PGA index after 4,8,12 weeks of treatment in the observation group were significantly lower than those in the control group( P ﹤ 0. 05),the decreased range of BASDAI and BASFI after 8,12 weeks of treatment in the observation group was more obvionsly( P ﹤ 0. 05);the 4 parameters of activity,adduction,internal rotation and flexion of the observation group increased significantly compared with the control group,ESR and CRP decreased significantly compared with the control group( P ﹤ 0. 05). The occurrence rate of adverse reactions in the observation group was 15. 00% ,which had no significant difference with 11. 67% in the control group ( P ﹥ 0. 05),and by the corresponding treatment,the adverse reactions were improved. Conclusion Etanercept combined with total hip replacement in treating ent of ankylosing spondylitis has better clinical efficacy, can provide sustained relief in patients with hip pain and improve the quality of life.关键词
依那西普/全髋关节置换术/强直性脊柱炎/临床疗效Key words
etanercept/total hip replacement/ankylosing spondylitis/clinical efficacy分类
医药卫生引用本文复制引用
江仁奇,张育民,王军,张聪明,王军伟,秦四清,马涛..依那西普治疗强直性脊柱炎60例疗效评价[J].中国药业,2015,(18):37-38,39,3.
